PAPP-A（小鼠）ELISA-PAPP-A (Mouse) ELISA代理/參數/廠家-ELISA試劑盒-艾美捷科技有限公司

PRODUCT CENTER

ELISA試劑盒

產品中心

當前位置：首頁 > 產品中心 > 免疫學產品 > ELISA試劑盒

中文名稱: PAPP-A（小鼠）ELISA

英文名字: PAPP-A (Mouse) ELISA

供應商: Ansh Labs

產品貨號: AL-158

產品報價: ￥詢價/96wellmicrotiter

產品說明書: 點擊查看

購買方式: 90%產品中國有現貨庫存。銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868

產品新聞

背景資料: Pregnancy-associated plasma protein-A (PAPP-A) is a novel zinc metalloproteinase that functions in many systems outside of pregnancy. PAPP-A expression has been reported in various tissues, including endometrium, testis, kidney, bone, colon, and other adult and fetal tissues.1-12 Abundant PAPP-A mRNA expression levels were found in visceral fat and these were 10-fold higher than in subcutaneous fat.10 PAPP-A expression significantly increases with age in kidney, brain and gonads10 and significantly deceases with age in bone and skeletal muscle.10 In the thymus, PAPP-A mRNA showed a biphasic response with age.10 Data in both humans and mice suggest a role for PAPP-A in aging and age-related diseases.10 Expression of IGFBP-5 mRNA, a marker of insulin-like growth factor-I (IGF-I) bioactivity known to be regulated by PAPP-A, paralleled the changes in PAPP-A expression with age in kidney, bone, skeletal muscle and thymus. PAPP-A is potentially proatherosclerotic and has been proposed as a new marker of inflammation, as high serum PAPP-A levels are observed in patients with renal impairment, asthma, lung cancer, etc.1-12 Stimulation of PAPP-A expression by intermittent PTH treatment contributes to PTH bone anabolism in mice.9 Effect of PAPP-A on tendon structure and mechanical properties have been studied8, However, quantitative determination of PAPP-A in mouse tissues with age are limited due to unavailability of the mouse PAPP-A ELISA.
n
nReferences:
n1. Bulut I, Coskun A, Ciftci A et al. Relationship between Pregnancy associated plasma protein A and lung cancer. The American Journal of the Medical sciences. April 2009; 337 (4): 241-244
n2. Schindler AM, Bischof B. Histochemical localization of pregnancy associated plasma protein-A in fetal, infant, and adult organs and camparison between antisera. Gynecol Obstet Invest. 1984; 18: 88-94.
n3. Overgaard MT, Oxvig C, Christiansen M , et al. Messenger ribonucleic acid levels of pregnancy-associated plasma protein-A and the preform of eosinophil major basic protein: expression in human reproductive and nonreproductive tissue. Biol Reprod 1999; 61:1083-1089.
n4. Fialova L, Kalousova M, Soukupova J, et al. Relationship of pregnancy associated plasma protein A to renal function and dialysis modalities. Kidney Blood Press Res. 2004; 27: 88-95.
n5. Coskun A, Balbay O, Duran S et al. Pregnancy-associated plasma protein A and asthama. Adv Ther. 2007; 24: 362-367.
n6. Coskun A, Duran S, Apaydin S, et al. Pregnancy-associated plasma protein A: evaluation of a new biomarker in renal transplanted patients. Transplant Proc. 2007; 39:3072-3076.
n7. Bayes-Genis A, Conover CA, Overgaard MT, et al. Pregnancy-associated plasma protein A as a marker of acute coronary syndromes. N Engl J Med. 2001; 345: 1022-1029.
n8. Yang TH, et al. PAPP-A affects tendon structure and mechanical properties. J Struct Biol. Oct 2015; 192(1):59-66.
n9. Clifton KB, et al. Pregnancy-associated plasma protein-A modulates the anabolic effects of parathyroid hormone in mouse bone. Bone. Dec 2015; 81:413-6.
n10. Harstad SL, et al. Tissue-specific changes in pregnancy associated plasma protein-A expression with age in mice. Endocrinology. Sep 2014; 57:13-7.
n11. Bale LK, et al. Inducible reduction in pregnancy-associated plasma protein-A gene expression inhibits established atherosclerotic plaque progression in mice. Endocrinology, Apr 2014; 155(4):1184-7.
n12. Conover CA, et al. Preferential impact of pregnancy-associated plasma protein-A deficiency on visceral fat in mice on high-fat diet. Am J Physiol Endocrinol Metab. Nov 2013; 305(9):E1145-53.
n13. HHS Publication, 5th ed., 2007. Biosafety in Microbiological and Biomedical Laboratories. Available http://www.cdc.gov/biosafety/publications/bmbl5/BMBL5
n14. DHHS (NIOSH) Publication No. 78–127, August 1976. Current Intelligence Bulletin 13 - Explosive Azide Hazard. Available http:// www.cdc.gov/niosh.
n15. Approved Guideline – Procedures for the Handling and Processing of Blood Specimens, H18-A3. 2004. Clinical and Laboratory Standards Institute.
n16. Kricka L. Interferences in immunoassays – still a threat. Clin Chem 2000; 46: 1037–1038.

產品描述: The Mouse PAPP-A enzyme linked immunosorbent assay (ELISA) kit provides materials for the quantitative measurement of PAPP-A in mouse serum, cell supernatant, and other biological fluids.

產品特點

保存建議: Store at 2 to 8°C until expiration date.

其他: Ansh labs是開發和生產免疫檢測試劑盒和定制生物技術檢測產領創者，總部位于美國休斯敦，公司產品遍及全球80多個國家。公司于2011年成立，核心團隊來自于Diagnostic system laboratory，專注于女性健康和激素檢測領域近40年，擁有全球領先的核心技術，以及多年經驗生物技術研發經驗的科學家團隊，產品覆蓋生殖健康，高危妊娠，腫瘤，糖尿病等多個疾病領域，圍繞最新的免疫分析技術，多種蛋白和單克隆抗體，如AMH，BMP-15, Follistatin, GDF-9, IGF-I, IGF-II, IGFBP-2, IGFBP-3, IGFBP-4, IGFBP-5, Inhibin Alpha, Inhibin ?A, Inhibin ?B, MBP, PAPP-A, PAPP-A2 and Vitamin D.等幾十余種試劑產品，也同時涵蓋小鼠，大鼠，狗，羊，牛等靈長類多個物種的獨特的物種特異性的試劑。 Ansh labs 坐落于美國德克薩斯州，是目前世界上唯一能提供TGF-β超家族所有成員的檢測公司，也是最早專注激素類產品研究和新型免疫檢測技術的先驅者。優勢產品涉及TGF-β super family、AMH/抑制素B(human/animal)、full panel IGFs、以及最完整的胰高血糖素系列。