Stanniocalcin 2 ELISA-Stanniocalcin 2 ELISA代理/參數/廠家-ELISA試劑盒-艾美捷科技有限公司

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中文名稱: Stanniocalcin 2 ELISA

英文名字: Stanniocalcin 2 ELISA

供應商: Ansh Labs

產品貨號: AL-143

產品報價: ￥詢價/96wellmicrotiter

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背景資料: Stanniocalcins, STC1 and STC2 are glycoprotein hormones. They were originally identified in fish, where they regulate calcium and phosphate homeostasis. Human STC2 is a 33.3 kDa protein, known to form disulfide-linked homodimers. The amino acid sequence of STC2 is only 30% identical to STC1, but the glycosylation sites and cysteine residues are conserved. STC2 is phosphorylated by Casein kinase 2. STC2 is widely expressed with most abundant protein expression in brain, adrenal gland, kidney, prostate and small intestine. 1
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nSTC2 function in hormone signaling is indicated by reports showing inhibition of ovarian progesterone biosynthesis and transactivation of androgen receptor.2,3 STC2 exhibits anti-apoptotic functions in cells subjected to endoplasmic reticulum and hypoxic stress by a mechanism involving inhibition of plasma membrane store-operated calcium entry.4,5 STC2 overexpression mice exhibit growth restriction, while knockout mice are larger than wild-type littermates.1 STC2 function in growth regulation was demonstrated by its ability to interact with PAPP-A, potentially inhibiting its proteolytic activity towards IGFBP-4 and causing reduced IGF signaling. 6,7,8 STC2-mediated PAPP-A inhibition was also reported to reduce atherosclerosis in hypercholesterolemic mice. 9
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nIn breast cancer STC2 is induced by estrogen and STC2 expression levels correlate with levels of estrogen receptor. STC2 function in different cancers may involve regulation of cell proliferation, neoplastic transformation and endothelial invasion. STC2 also plays a role in epithelial-mesenchymal transition by activation of MAPK/ERK signaling in hypoxic ovarian cancer cells. STC2 is upregulated in several cancers including, gastric cancer, lung cancer, renal cell carcinoma, colorectal cancer, castration-resistant prostate cancer and cervical cancer.1 Serum STC2 levels may serve as a valuable research tool for diagnosis and prognosis of several cancers and growth defects.
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nReferences:
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n1. Yeung BH, Law AY, Wong CK. 2012. Evolution and roles of stanniocalcin. Mol Cell Endocrinol. 26;349(2):272-80.
n2. Shin J, Sohn YC. 2014. Identification of Ran-binding protein M as a stanniocalcin 2 interacting protein and implications for androgen receptor activity. BMB Rep. 47(11):643-8.
n3. Luo, C.W., Pisarska, M.D., Hsueh, A.J., 2005. Identification of a stanniocalcin paralog, stanniocalcin-2, in fish and the paracrine actions of stanniocalcin-2 in the mammalian ovary. Endocrinology 146, 469–476.
n4. Ito, D., Walker, J.R., Thompson, C.S., Moroz, I., Lin, W., Veselits, M.L., Hakim, A.M.,Fienberg, A.A., Thinakaran, G., 2004. Characterization of stanniocalcin 2, a novel target of the mammalian unfolded protein response with cytoprotective properties. Mol. Cell Biol. 24, 9456–9469.
n5. Zeiger, W., Ito, D., Swetlik, C., Oh-hora, M., Villereal, M.L., Thinakaran, G., 2011. Stanniocalcin 2 is a negative modulator of store-operated calcium entry. Mol.Cell Biol. 31, 3710–3722.
n6. Jepsen MR, Kl?verpris S, B?tkj?r JA, Wissing ML, Andersen CY, Oxvig C. 2016.The proteolytic activity of pregnancy-associated plasma protein-A is potentially regulated by stanniocalcin-1 and -2 during human ovarian follicle development. Hum Reprod. 31(4):866-74
n7. Monget P, Oxvig C. 2016. PAPP-A and the IGF system. Ann Endocrinol (Paris). 77(2):90-6
n8. Jepsen MR, Kl?verpris S, Mikkelsen JH, Pedersen JH, Füchtbauer EM, Laursen LS, Oxvig C. 2015. Stanniocalcin-2 inhibits mammalian growth by proteolytic inhibition of the insulin-like growth factor axis. J Biol Chem 6;290(6):3430-9
n9. Steffensen LB, Conover CA, Bj?rklund MM, Ledet T, Bentzon JF, Oxvig C.2016. Stanniocalcin-2 overexpression reduces atherosclerosis in hypercholesterolemic mice. Atherosclerosis, 248:36-43
n10. HHS Publication, 5th ed., 2007. Biosafety in Microbiological and Biomedical Laboratories. Available http://www.cdc.gov/biosafety/publications/bmbl5/BMBL5
n11. DHHS (NIOSH) Publication No. 78–127, August 1976. Current Intelligence Bulletin 13 - Explosive Azide Hazard. Available http:// www.cdc.gov/niosh.
n12. Approved Guideline – Procedures for the Handling and Processing of Blood Specimens, H18-A3. 2004. Clinical and Laboratory Standards Institute.
n13. Kricka L. Interferences in immunoassays – still a threat. Clin Chem 2000; 46: 1037–1038.

產品描述: The Stanniocalcin-2 (STC2) enzyme linked immunosorbent assay (ELISA) kit provides materials for the quantitative measurement of Stanniocalcin-2 in human serum and other biological fluids.

產品特點

保存建議: Store at 2 to 8°C until expiration date.

其他: Ansh labs是開發和生產免疫檢測試劑盒和定制生物技術檢測產領創者，總部位于美國休斯敦，公司產品遍及全球80多個國家。公司于2011年成立，核心團隊來自于Diagnostic system laboratory，專注于女性健康和激素檢測領域近40年，擁有全球領先的核心技術，以及多年經驗生物技術研發經驗的科學家團隊，產品覆蓋生殖健康，高危妊娠，腫瘤，糖尿病等多個疾病領域，圍繞最新的免疫分析技術，多種蛋白和單克隆抗體，如AMH，BMP-15, Follistatin, GDF-9, IGF-I, IGF-II, IGFBP-2, IGFBP-3, IGFBP-4, IGFBP-5, Inhibin Alpha, Inhibin ?A, Inhibin ?B, MBP, PAPP-A, PAPP-A2 and Vitamin D.等幾十余種試劑產品，也同時涵蓋小鼠，大鼠，狗，羊，牛等靈長類多個物種的獨特的物種特異性的試劑。 Ansh labs 坐落于美國德克薩斯州，是目前世界上唯一能提供TGF-β超家族所有成員的檢測公司，也是最早專注激素類產品研究和新型免疫檢測技術的先驅者。優勢產品涉及TGF-β super family、AMH/抑制素B(human/animal)、full panel IGFs、以及最完整的胰高血糖素系列。