催產調節蛋白 ELISA-Oxyntomodulin ELISA代理/參數/廠家-ELISA試劑盒-艾美捷科技有限公司

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中文名稱: 催產調節蛋白 ELISA

英文名字: Oxyntomodulin ELISA

供應商: Ansh Labs

產品貨號: AL-139

產品報價: ￥詢價/96wellmicrotiter

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產品新聞

背景資料

Oxyntomodulin was initially identified as a moiety that exhibited glucagon like immunoreactivity and was appropriately named for its ability to modulate the gastric acid secretion in the gastric oxyntic glands.1,2 Oxyntomodulin is a 37 amino acid peptide hormone secreted by the gut endocrine L-cells post-prandially3. Oxyntomodulin and Glucagon, a peptide hormone secreted by the alpha cells of the pancreas, share the identical amino acid sequence in the N-terminal 29 aa with oxyntomodulin having an additional octapeptide in the C-terminus. Upon nutrient ingestion, prohormone convertase1/3 cleaves proglucagon precursor into Oxyntomodulin, GLP-1/2 and GRPP.3
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nOxyntomodulin is known to bind both the GLP-1 receptor (GLP1R) and the glucagon receptor (GCGR), but with lower affinity compared to GLP-1 and glucagon.3
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nOxyntomodulin causes weight loss in obese patients via suppression of food intake and increase in energy expenditure.3 It is reported to have varied tissue-specific effects; and stimulates endocrine pancreas to secrete insulin, somatostatin and glucagon. Oxyntomodulin administration was also reported to increase heart-rate in mice.3 Besides regulating glucose homeostasis in monogastric animals, oxyntomodulin also increases the concentration of insulin and glucose in plasma of Holstein cattle under normal physiological conditions.4 Using mass-spectrometry based profiling of human plasma, it was shown that Type 2 diabetes patients have lower levels of Oxyntomodulin and levels increase more than 10-fold after gastric bypass surgery.5 Oxyntomodulin is therapeutically used to lower glucose levels and suppress appetite resulting in weight loss.
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nReferences:
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Unger, R.H., Eisentraut,A.M.,McCall,M.S.,Keller,S.,Lanz,H.C.,Madison,L.L., 1959. Glucagon antibodies and their use for immunoassay for glucagon. Proceedings of the Society for Experimental Biology and Medicine 102:621–623.

Bataille, D., Tatemoto,K.,Coudray,A.M.,Rosselin,G.,Mutt,V.,1981.Bioactive ‘enteroglucagon’ (oxyntomodulin):evidence for a C-terminal extension of the glucagon molecule. Comptes Rendus des Séances de l'Académie des Sciences. Série III 293:323–328.

Pocai A. 2012. Unraveling oxyntomodulin, GLP1's enigmatic brother. J Endocrinol. 215(3):335-46

ThanThan S, Zhao H, Yannaing S, Ishikawa T, Kuwayama H.2010. Oxyntomodulin increases the concentrations of insulin and glucose in plasma but does not affect ghrelin secretion in Holstein cattle under normal physiological conditions. Domest Anim Endocrinol. 39(3):163-70

Wewer Albrechtsen NJ et al; 2016. Oxyntomodulin Identified as a Marker of Type 2 Diabetes and Gastric Bypass Surgery by Mass-spectrometry Based Profiling of Human Plasma. EBioMedicine.7:112-20.

HHS Publication, 5th ed., 2007. Biosafety in Microbiological and Biomedical Laboratories. Available http://www.cdc.gov/biosafety/publications/bmbl5/BMBL5

DHHS (NIOSH) Publication No. 78–127, August 1976. Current Intelligence Bulletin 13 - Explosive Azide Hazard. Available: http:// www.cdc.gov/niosh.

Kricka L. Interferences in immunoassays – still a threat. Clin Chem 2000; 46: 1037–1038.

產品描述: The Oxyntomodulin (OXM) ELISA (enzyme linked immunosorbent assay) kit provides materials for the quantitative measurement of oxyntomodulin in K²-EDTA and Li-Heparin plasma and other biological fluids.

產品特點

保存建議: Store at 2 to 8°C until expiration date.

其他: Ansh labs是開發和生產免疫檢測試劑盒和定制生物技術檢測產領創者，總部位于美國休斯敦，公司產品遍及全球80多個國家。公司于2011年成立，核心團隊來自于Diagnostic system laboratory，專注于女性健康和激素檢測領域近40年，擁有全球領先的核心技術，以及多年經驗生物技術研發經驗的科學家團隊，產品覆蓋生殖健康，高危妊娠，腫瘤，糖尿病等多個疾病領域，圍繞最新的免疫分析技術，多種蛋白和單克隆抗體，如AMH，BMP-15, Follistatin, GDF-9, IGF-I, IGF-II, IGFBP-2, IGFBP-3, IGFBP-4, IGFBP-5, Inhibin Alpha, Inhibin ?A, Inhibin ?B, MBP, PAPP-A, PAPP-A2 and Vitamin D.等幾十余種試劑產品，也同時涵蓋小鼠，大鼠，狗，羊，牛等靈長類多個物種的獨特的物種特異性的試劑。 Ansh labs 坐落于美國德克薩斯州，是目前世界上唯一能提供TGF-β超家族所有成員的檢測公司，也是最早專注激素類產品研究和新型免疫檢測技術的先驅者。優勢產品涉及TGF-β super family、AMH/抑制素B(human/animal)、full panel IGFs、以及最完整的胰高血糖素系列。