- 中文名稱
雌三醇，未結合 EIA
- 英文名字
- Estriol, Unconjugated EIA
- 供應商
- Ansh Labs
- 產品貨號
- AL-138
- 產品報價
- ￥詢價/96wellmicrotiter
- 產品說明書
- 點擊查看
- 購買方式
- 90%產品中國有現貨庫存。銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868
- 產品新聞
- 背景資料
- Estriol (1,3,5(10)-estratriene-3,16α,17β-triol; E3) is one of the 3 major naturally occurring estrogens, the others being estradiol and estrone.? Estriol is produced almost exclusively during pregnancy, and is the major estrogen produced in the normal human fetus. During pregnancy, the production of estriol depends on an intact maternal-placental-fetal unit.1,2 Steroid precursors from the maternal circulation are taken up by the placenta and converted to progesterone.? Progesterone is then converted to dehydroepiandrosterone sulfate (DHEA-S) in the fetal adrenal gland, which is then 16α-hydroxylated in the fetal liver.? 16α-hydroxylase activity is present in only very low amounts in placenta and non-fetal tissues.? In the placenta, 16α-hydroxy-DHEA-S is then converted sequentially to 16α-hydroxy-DHEA, 16α-hydroxyandrost-4-ene-3,17-dione and, finally, estriol. Estriol may also originate from estrogen precursors, such as 16α-hydroxyestrone.? This pathway may account for the high levels of estrone sulfate found in breast cyst fluid.3
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nFetal-placental production of estriol leads to a progressive rise in maternal circulating estriol levels, reaching a late-gestational peak which is ~2-3 orders of magnitude greater than non-pregnant levels.1,2 In the maternal circulation, estriol undergoes rapid conjugation in the liver followed by urinary excretion with a half-life of ~20 minutes.1 Therefore, maternal estriol levels can provide a dynamic estimate of fetal production rates. In terms of estrogenic activity, estriol is much less potent than estradiol.2 The physiologic role of estriol is not known.
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nSpecific diagnostic and therapeutic uses for estriol measurements are not completely defined, although clinical utility during pregnancy has been investigated.? Since normal estriol production depends on an intact maternal-placental-fetal circulation and functional fetal metabolism, maternal estriol levels have been used to monitor fetal status during pregnancy, particularly during the third trimester.? Because estriol concentrations are subject to diurnal and episodic variation, it is common practice to refer serum measurements to a baseline, defined for the patient as either the average or the highest of her three most recent estriol results.? However, studies in diabetic pregnancies suggest that low estriol levels have limited value in predicting fetal distress.4 The AL-138 Unconjugated Estriol EIA uses a rabbit anti-estriol antibody preparation with low cross-reactivity to other natural estrogens and estrogen precursors.
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nReferences:
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n1. Buster JE: Gestational changes in steroid hormone biosynthesis, secretion, metabolism, and action.? Clin Perinatol 10:527-552, 1983.
n2. Ca?ez MS, Lee KJ, Olive DL: Progestogens and estrogens. Infertil Reproduct Med Clin North Amer 3:59-78, 1992.
n3. Levitz M, Raju U, Arcuri F, Brind JL, Vogelman JH, Orentreich N, Granata OM, Castagnetta L: Relationship between the concentrations of estriol sulfate and estrone sulfate in human breast cyst fluid.? J Clin Endocrinol Metab 75:726-729, 1992.
n4. Miodovnik M, Mimouni F, Hertzberg VS, Siddiqi TA, Tsang RC: Serum unconjugated estriols in insulin-dependent diabetic pregnancies: normative data and clinical relevance. Am J Perinatol 5:327-333, 1988.
n5. HHS Publication, 5th ed., 2007. Biosafety in Microbiological and Biomedical Laboratories. Available http://www.cdc.gov/biosafety/publications/bmbl5/BMBL5
n6. Approved Guideline – Procedures for the Handling and Processing of Blood Specimens, H18-A3. 2004. Clinical and Laboratory Standards Institute.
n7. Kricka L. Interferences in immunoassays – still a threat. Clin Chem 46: 1037–1038, 2000.
- 產品描述
- The Unconjugated Estriol Enzyme Immunoassay (EIA) Kit provides materials for the quantitative measurement of unconjugated estriol in serum.
- 產品特點
- 保存建議
- Store at 2 to 8°C until expiration date.
- 其他
- Ansh labs是開發和生產免疫檢測試劑盒和定制生物技術檢測產領創者，總部位于美國休斯敦，公司產品遍及全球80多個國家。公司于2011年成立，核心團隊來自于Diagnostic system laboratory，專注于女性健康和激素檢測領域近40年，擁有全球領先的核心技術， 以及多年經驗生物技術研發經驗的科學家團隊，產品覆蓋生殖健康，高危妊娠，腫瘤，糖尿病等多個疾病領域，圍繞最新的免疫分析技術，多種蛋白和單克隆抗體，如AMH，BMP-15, Follistatin, GDF-9, IGF-I, IGF-II, IGFBP-2, IGFBP-3, IGFBP-4, IGFBP-5, Inhibin Alpha, Inhibin ?A, Inhibin ?B, MBP, PAPP-A, PAPP-A2 and Vitamin D.等幾十余種試劑產品，也同時涵蓋小鼠，大鼠，狗，羊，牛等靈長類多個物種的獨特的物種特異性的試劑。
Ansh labs 坐落于美國德克薩斯州，是目前世界上唯一能提供TGF-β超家族所有成員的檢測公司，也是最早專注激素類產品研究和新型免疫檢測技術的先驅者。優勢產品涉及TGF-β super family、AMH/抑制素B(human/animal)、full panel IGFs、以及最完整的胰高血糖素系列。
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- 注意
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該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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