卵泡抑素 ELISA-Follistatin ELISA代理/參數/廠家-ELISA試劑盒-艾美捷科技有限公司

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中文名稱: 卵泡抑素 ELISA

英文名字: Follistatin ELISA

供應商: Ansh Labs

產品貨號: AL-117

產品報價: ￥詢價/96wellmicrotiter

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背景資料: Follistatin (FST) is a glycosylated single-chain protein that is expressed in a wide variety of tissues.1 Activin stimulates pituitary FSH secretion whereas Inhibin and Follistatin are inhibitory.2 Follistatin has been shown to be a potent activin-binding protein which acts by neutralizing the actions of the Activins.3 The activin-follistatin binding complex is generally considered to be composed of one activin and two follistatin molecules, and the affinity of binding between follistatin and activin is similar to that of activin for its receptor. Several isoforms of follistatin of molecular weight 31 – 39 kDa have been identified. Molecular analysis of the isoforms indicate that follistatin is encoded by a single gene and that the variety of isoforms arise from alternative splicing, glycosylation and proteolytic cleavage. Alternative splicing occurs at the 3’-terminal of the gene resulting in a precursor form of 317 and 344 amino acids4, and then following subsequent cleavage of the 29 amino acid signal peptide, generates 2 mature follistatin isoforms of 288 and 315 amino acids (namely Follistatin-288 and Follistatin-315).
nThe ratio of Follistatin isoforms present in different tissues and bodily fluids varies, as does their relative binding affinities. Follistatin-288 is the predominant form present in human follicular fluid; whereas the main form in serum is Follistatin-315.5 Follistatin-288 has a greater capacity to bind and neutralize activin and is approximately 10-fold more potent than Follistatin-315 in suppressing FSH secretion from rat pituitary cells in vitro. In addition, Follistatin-288 also binds with much greater affinity to heparin sulfate proteoglycans located on the cell surface and extracellular matrix, indicating that the Follistatin-288 isoform is primarily a membrane-bound form of Follistatin, whereas Follistatin-315 is a circulating form.
n
nReferences:
n1. Lin SY et al. Reproduction. 126(2):133-148, 2003.
n2. Robertson DM et al. Biochem Biophys Res Commun. 126(1):220-226, 1985.
n3. Nakamura T et al. Science. 247(4944):836-838, 1990.
n4. Shimasaki S et al. Biochem Biophys Res Commun. 152(2):717-723, 1988.
n5. Schneyer AL et al. Endocrinology. 137(1):240-247, 1996.
n6. HHS Publication, 5th ed., 2007. Biosafety in Microbiological and Biomedical Laboratories. Available http://www.cdc.gov/biosafety/publications/bmbl5/BMBL5
n7. DHHS (NIOSH) Publication No. 78–127, August 1976. Current Intelligence Bulletin 13 - Explosive Azide Hazard. Available http:// www.cdc.gov/niosh.

產品描述: The Follistatin enzyme linked immunosorbent assay (ELISA) kit provides materials for the quantitative measurement of follistatin in human serum and other biological fluids.

產品特點

保存建議: Store at 2 to 8°C until expiration date.

其他: Ansh labs是開發和生產免疫檢測試劑盒和定制生物技術檢測產領創者，總部位于美國休斯敦，公司產品遍及全球80多個國家。公司于2011年成立，核心團隊來自于Diagnostic system laboratory，專注于女性健康和激素檢測領域近40年，擁有全球領先的核心技術，以及多年經驗生物技術研發經驗的科學家團隊，產品覆蓋生殖健康，高危妊娠，腫瘤，糖尿病等多個疾病領域，圍繞最新的免疫分析技術，多種蛋白和單克隆抗體，如AMH，BMP-15, Follistatin, GDF-9, IGF-I, IGF-II, IGFBP-2, IGFBP-3, IGFBP-4, IGFBP-5, Inhibin Alpha, Inhibin ?A, Inhibin ?B, MBP, PAPP-A, PAPP-A2 and Vitamin D.等幾十余種試劑產品，也同時涵蓋小鼠，大鼠，狗，羊，牛等靈長類多個物種的獨特的物種特異性的試劑。 Ansh labs 坐落于美國德克薩斯州，是目前世界上唯一能提供TGF-β超家族所有成員的檢測公司，也是最早專注激素類產品研究和新型免疫檢測技術的先驅者。優勢產品涉及TGF-β super family、AMH/抑制素B(human/animal)、full panel IGFs、以及最完整的胰高血糖素系列。