IGFBP-5（大鼠和小鼠）ELISA-IGFBP-5 (Rat and Mouse) ELISA代理/參數/廠家-ELISA試劑盒-艾美捷科技有限公司

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背景資料: Insulin-like growth factor binding protein 5 (IGFBP-5) is part of the IGF-binding proteins that regulates IGF activity by binding to IGF ligands. The IGF axis consists of six high-affinity IGF-binding proteins (IGFBP 1-6). IGFBP-5 has 272 amino acids and weighs about 31 kDa. IGF axis is the principal endocrine system that regulates the differentiation, development, and maintenance of bone tissue. Dysfunction of this axis is associated with various skeletal pathologies such as growth disorders and abnormal bone structure. (1,2)
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nPregnancy-Associated Plasma Protein-A2 (PAPP-A2) plays a major role in bone cell physiology as well. PAPP-A2 is also known to proteolyze IGFBP-5. Certain mutation in the PAPP-A2 protein inhibits its ability to proteolyze IGFBP-5. Consequently, affected individuals show microcephaly, mild BMD effects and thin long bones. Thus, IGFBP-5 plays an important role in osteoblast differentiation and bone tissue metabolism which remains to be further expounded upon. (1,2)
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nReferences:
n1. Beattie et al. Insulin- like Growth Factor-Binding Protein Action in Bone Tissue: A Key Role for Pregnancy- Associated Plasma Protein-A. Front. Endocrinol., 2018
n2. Duan, Cunming, and John B Allard. “Insulin-Like Growth Factor Binding Protein-5 in Physiology and Disease.” Frontiers in endocrinology vol. 11 100. 3 Mar. 2020, doi:10.3389/fendo.2020.00100

產品描述: The Total Rat/Mouse IGFBP-5 enzyme linked immunosorbent assay (ELISA) kit provides materials for the quantitative measurement of IGFBP-5 in mouse and rat samples.

其他: Ansh labs是開發和生產免疫檢測試劑盒和定制生物技術檢測產領創者，總部位于美國休斯敦，公司產品遍及全球80多個國家。公司于2011年成立，核心團隊來自于Diagnostic system laboratory，專注于女性健康和激素檢測領域近40年，擁有全球領先的核心技術，以及多年經驗生物技術研發經驗的科學家團隊，產品覆蓋生殖健康，高危妊娠，腫瘤，糖尿病等多個疾病領域，圍繞最新的免疫分析技術，多種蛋白和單克隆抗體，如AMH，BMP-15, Follistatin, GDF-9, IGF-I, IGF-II, IGFBP-2, IGFBP-3, IGFBP-4, IGFBP-5, Inhibin Alpha, Inhibin ?A, Inhibin ?B, MBP, PAPP-A, PAPP-A2 and Vitamin D.等幾十余種試劑產品，也同時涵蓋小鼠，大鼠，狗，羊，牛等靈長類多個物種的獨特的物種特異性的試劑。 Ansh labs 坐落于美國德克薩斯州，是目前世界上唯一能提供TGF-β超家族所有成員的檢測公司，也是最早專注激素類產品研究和新型免疫檢測技術的先驅者。優勢產品涉及TGF-β super family、AMH/抑制素B(human/animal)、full panel IGFs、以及最完整的胰高血糖素系列。