Acetylation of proteins can occur as a co-translational or post-translational modification? (PTM) .? Co-translational acetylation occurs at the N-terminal of approximately 85% of mammalian proteins, it is irreversible and is thought to be important in protein stability, localization and synthesis .? Post-translational acetylation occurs on the epsilon amino group of lysine residues as a reversible and highly dynamic PTM that is known to be a key regulator in multiple cellular events, including chromatin structure, transcription,? metabolism,? signal transduction and cytoskeletal regulation.? To date over 4,000 proteins have been identified as targets for PTM acetylation which is comparable to phosphorylation in cellular prevelance .? Antibody AAC01 detects acetyl lysine PTMs.?
