- 中文名稱
針對扎伊爾埃博拉病毒 GP 蛋白的人單克隆 scFv-Fc 抗體
- 英文名字
- Human monoclonal scFv-Fc antibody to Zaire Ebolavirus GP protein
- 供應商
- Icosagen
- 產品貨號
- A2-101-100
- 產品報價
- ￥詢價/100ug ￥500ug ￥1mg
- 產品說明書
- 點擊查看
- 購買方式
- 銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868。
- 產品新聞
- 背景資料
- GP1 is responsible for binding to the receptors on target cells. Interacts with CD209/DC-SIGN and CLEC4M/DC-SIGNR which act as cofactors for virus entry into the host cell. Binding to CD209 and CLEC4M, which are respectively found on dendritic cells (DCs), and on endothelial cells of liver sinusoids and lymph node sinuses, facilitate infection of macrophages and endothelial cells. These interactions not only facilitate virus cell entry, but also allow capture of viral particles by DCs and subsequent transmission to susceptible cells without DCs infection (trans infection). GP2 acts as a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.GP1,2 mediates endothelial cell activation and decreases endothelial barrier function. Mediates activation of primary macrophages. At terminal stages of the viral infection, when its expression is high, GP1,2 down-modulates the expression of various host cell surface molecules that are essential for immune surveillance and cell adhesion. Down-modulates integrins ITGA1, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGAV and ITGB1. GP1,2 alters the cellular recycling of the dimer alpha-V/beta-3 via a dynamin-dependent pathway. Decrease in the host cell surface expression of various adhesion molecules may lead to cell detachment, contributing to the disruption of blood vessel integrity and hemorrhages developed during Ebola virus infection (cytotoxicity). (Ebola GP1 and 2 functions, UniProt).
- 應用類型
- ELISA, WB, IF
- 免疫原
- Ebolavirus GP protein
- 來源宿主
- 單克隆：兔 scFv、人 Fc
- 反應性
- Zaire Ebolavirus GP protein
- 保存建議
- Store at -20…-70°C upon receipt. Divide antibody into aliquots prior usage. Avoid multiple freeze-thaw cycles
- 其他
- Icosagen AS成立于1999年，總部位于愛沙尼亞，提供一系列現成產品，如抗體、蛋白質、ELISA試劑盒等，以及天然橡膠過敏原檢測和食品質量控制領域的質量控制服務。產品涵蓋的應用領域有：神經生物學，病毒學，心臟標志物，細胞因子，炎癥，過敏原等。Icosagen提供用于診斷和研究的重組抗體和抗原。Icosagen將現代重組技術和20年的制藥經驗引入診斷領域，以開發和生產高質量的試劑。利用Icosagen的專利系列，開發和生產高親和力和特異性的單克隆和多克隆抗體。Icosagen已通過ISO 9001:2015認證，并遵循GLP指南。
- 注意
-
該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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