Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family，impairs their association with C/EBP binding sites in the promoter regions，and inhibits the expression of C/EBP regulated genes. ositively regulates the transcription of TRIB3，IL6，IL8，IL23，TNFRSF10B/DR5，PPP1R15A/GADD34，BBC3/PUMA，BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1，ATF4-dependent transcriptional activation of asparagine synthetase (ASNS)，CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG).
應用類型
WB, IHC, IF
免疫原
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human DDIT3
