Platelet-derived growth factor (PDGF) refers to a family of disulphide-bonded dimeric isoforms that are important for growth and survival，and which function in several types of connective tissue cell. There are four members of the platelet-derived growth factor (PDGF) family: PDGF-A，PDGF-B，PDGF-C and PDGF-D (spinal cord-derived growth factor-B or iris-expressed growth factor). Their biological effects are mediated via two tyrosine kinase receptors，PDGFR- and PDGFR-B. PDGF-mediated signaling is critical for development of many organ systems. PDGF-D has a two-domain structure similar to PDGF-C and is secreted as a disulphide-linked homodimer，PDGF-DD. Upon limited proteolysis，PDGF-DD is activated and becomes a specific agonistic ligand for PDGFR-B. PDGF-D is expressed in fibroblastic adventitial cells，cultured endothelial cells and in a variety of tumor cell lines.
應用類型
WB, IHC
免疫原
A peptide corresponding to the C-terminus of human CD140b
