ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This mAb is specific to CLIP (aa 25-39 of ACTH); does not react with Synacthen (aa1-24 of ACTH). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive，tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP，ACTH，alpha-MSH (Melanocyte Stimulating Hormone)，beta-MSH，gamma-MSH，CLIP (corticotropin-like intermediary peptide)，Lipotropin-beta，Lipotropin-gamma，beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells，B-cells，and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs). It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH.
應用類型
ELISA, FC, ICC/IF, IHC
免疫原
Synthetic peptide corresponding to aa 25-39 of human ACTH (NGAEDESAEAFPLEF)
