CD58，also known as lymphocyte function-associated antigen 3 (LFA-3) is a 45-70 kD cell surface protein that is a member of the immunoglobulin superfamily. Alternative splicing of CD58 gives rise to transmembrane and glycosylphosphatidylinositol (GPI)-anchored forms on cell surface. CD58 is expressed on both hematopoietic and non-hematopoietic cells including B cells，T cells，monocytes，erythrocytes，endothelial cells，epithelial cells，and fibroblasts. High levels are observed on memory T cells and dendritic cells. CD58 expressed on antigen presenting cells and target cells enhances T cell recognition via the binding of its cognate ligand，CD2，on the T cell surface.
應用類型
WB: 1:500 - 1:1000
免疫原
This CD58 antibody is generated from KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CD58. The exact sequence is proprietary.
