Cyclin E1 is a regulatory subunit of the CDK2 kinase. It is central for the regulation of the G1/S transition and its abundance is tightly regulated throughout the cell cycle via ubiquitination. Cyclin E has been the subject of intense study in relation to tumorigenesis and cancer management and prognosis. Multiple isoforms of Cyclin E are only expressed in tumors but not in normal tissue，suggesting a post transcriptional regulation of Cyclin E. In vitro analyses indicated that these truncated variant isoforms of Cyclin E are able to phosphorylate histone H1. Alterations in the Cyclin E protein have been implicated as indicators of worse prognosis in various cancers.
This Cyclin E1 antibody is generated from KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Cyclin E1. The exact sequence is proprietary.
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠、大鼠、牛、狗、豬種屬來源的Cyclin E1蛋白發生免疫反應.
保存建議
提供的Cyclin E1抗體為無色溶液形式，產品濃度為1 mg/ml，溶解于包含有100 mM glycine與海藻糖的50 mM Tris緩沖液（pH 7.0）.請在收到該Cyclin E1抗體產品后，將其置于-20 °C冷凍保存，建議分裝使用以避免反復凍融.
