The c-Kit proto-oncogene is a member of the receptor tyrosine kinase family and，more specifically，is closely related to the platelet derived growth factor receptor （PDGFR）. c-Kit，the normal cellular homolog of the HZ4-feline sarcoma virus transforming gene （v-Kit），encodes a transmembrane receptor. c-Kit regulates a variety of biological responses including chemotaxis，cell proliferation，apoptosis，and adhesion. c-Kit is also identical with the product of the W locus in mice and，as such，is integral to the development of mast cells and hematopoiesis. The ligand for the c-Kit receptor （KL） has been identified and is encoded at the murine steel （SI） locus. Kit is the human homolog of the proto-oncogene c-Kit. Mutations in Kit are integral for tumor growth and progression in various cancers.
應用類型
WB: 1:1000， IHC: 1:10 – 1:50， IF: 1:10 – 1:50.
免疫原
This c-KIT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 9-40 amino acids from the N-terminal region of human c-KIT.
來源宿主
兔
反應性
經檢測驗證，可與人 種屬來源的C-Kit/CD117抗體（N末端）蛋白發生免疫反應.
保存建議
提供的C-Kit/CD117抗體（N末端）產品為無色溶液形式，含有100 ul抗體.該產品濃度為與批次相關，溶解于50 mM Tris-Glycine （pH 7.4）， 0.15 M NaCl， 40% 甘油， 0.01% sodium azide和0.05% BSA..請在收到該C-Kit/CD117抗體（N末端）產品后，將其置于-20 °C冷凍保存，建議分裝使用以避免反復凍融.
