AKR1A1 （aldo-keto reductase family 1 member A1），also known as ALR （aldehyde reductase），DD3 （dihydrodiol dehydrogenase 3） or ALDR1 （alcohol dehydrogenase），is a widely and abundantly expressed member of the aldo-keto reductase （AKR） family of proteins. Members of the AKR family are soluble NADPH-dependent oxidoreductases. They play important roles in the metabolism of drugs，carcinogens and reactive aldehydes. AKR1A1 exists as a monomer and catalyzes the reduction of xenobiotic and biogenic aldehydes and ketones to their corresponding alcohols. In particular，AKR1A1 efficiently catalyzes medium-chain and aromatic aldehydes. AKR1A1 participates in the biosynthetic pathways of cholesterol and triglyceride and plays a role in the activation of polycyclic aromatic hydrocarbons （PAHs）.
應用類型
Western blot: ~1:1000， IHC: ~1:10 – 1:50
免疫原
This AKR1A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 293-325 amino acids from the C-terminal region of human AKR1A1.
