The zinc finger protein 521 （ZNF521） is a transcription factor containing an N-terminal transcriptional repressor motif and 30 zinc finger domains. It plays a role in both erythroid cell and osteoblast differentiation during development，inhibiting the activities of early B-cell factor 1 （EBF1） in erythroid cells and Runx2 in osteoblast precursors. ZFP521 binds to both Runx2 and histone deacetylase 3 （HDAC3），promotes their association and antagonizes Runx2 transcriptional activity in a HDAC3-dependent manner，thereby regulating osteoblast differentiation，skeletal development，and bone homeostasis.
應用類型
IHC: 5 ug/ml， ELISA. However， the optimal conditions should be determined individually.
免疫原
ZNF521 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human ZNF521.
