TAB2 is an activator of MAP3K7/TAK1，which is required for for the IL-1 induced activation NF-kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6，MAP3K7 and TAB1，thus serves as an adaptor linking MAP3K7 and TRAF6. This protein，TAB1，and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKL through the activation of the receptor activator of NF-kappaB （TNFRSF11A/RANK），which may regulate the development and function of osteoclasts. Recent experiments have shown that TAB2 and the related protein TAB3 constitutitvely interact with the autophagy mediator Beclin-1； upon induction of autophagy，these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy，while their depletion triggers it，suggesting that TAB2 and TAB3 act as a control point for autophagy.
應用類型
Immunohistochemistry: 5 ug/ml， ELISA. However， the optimal conditions should be determined individually.
免疫原
TAB2 antibody was raised against a 14 amino acid peptide near the carboxy terminus of human TAB2.
