Heme oxygenase (HO) is a microsomal enzyme that oxidatively cleaves heme，a pro-oxidant，into carbon monoxide and biliverdin. Two heme oxygenase isozymes，termed HO-1 and HO-2，have been identified so far. At the amino acid level，HO-1 and HO-2 are 42% homologous. However，each isozyme is evolutionary highly conserved. HO-1 is the inducible form of the enzyme and is therefore also referred to as stress protein Hsp32. Expression of HO-1 can be induced by a variety of stimuli such as heme，metals，hormones，UV radiation and sulfhydryl depleting agents. In contrast，HO-2 is the constituitive form of the enzyme. It is not inducible by exogeneous stimuli and HO-2 is the most prevalent form in most tissues，except the spleen where HO-1 levels are predominant under normal conditions.
應用類型
Western blotting, Immunoprecipitation, Immunohistochemistry
免疫原
Synthetic peptide surrounding amino acid 34 of human HO-2
