Artemis is a 78 kDa protein，belonging to metallo-beta-lactamase superfamily. It is involved in endonuclease activity to break DNA hairpins. It also has been reported that the C-terminus of Artemis interacts with DNA binding domain of Ligase IV directly. Ligase IV is a key enzyme in DNA repair and V（D）J recombination. Thus，Artemis is a novel protein that is involved in V（D）J recombination/DNA repair. Mutations cause human T-B-severe combined immunodeficiency associated with increased cellular radiosensitivity （RS-SCID）.
應用類型
Western blot: 1:200
免疫原
Synthetic peptide surrounding the C-terminal （BV-M21）
