- 中文名稱
Latanoprost (free acid)-d4 (5 mg)
- 英文名字
- 17-phenyl-13,14-dihydro trinor Prostaglandin F2
- 供應商
- Cayman
- 產品貨號
- 316811-5
- 產品報價
- ￥24360/5 mg
- 產品說明書
- 點擊查看
- 購買方式
- 產品新聞
- 背景資料
- Latanoprost (free acid)-d4 (Lat-FA-d4) contains four deuterium atoms at the 3, 3, 4, and 4 positions. It is intended for use as an internal standard for the quantification of Lat-FA by GC- or LC-mass spectrometry. Latanoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug. It is the isopropyl ester of a PGF2.alpha. analog containing an aromatic group (17-phenyl) in the .omega.-chain. As an isopropyl ester, latanoprost acts as a prodrug which is converted to Lat-FA by endogenous esterase enzymes. Lat-FA is a potent FP receptor agonist with an EC50 value of 3.6 nM for human FP receptors, which is twice the potency of PGF2.alpha. and more than 200 times more potent latanoprost. The efficacy of PG analog esters for the treatment of glaucoma correlates closely with the FP receptor binding affinity of the free acid. However, Lat-FA is more irritating and less effective than the prodrug latanoprost when applied directly to the eyes of human glaucoma patients.
- 產品描述
- An internal standard for the quantification of latanoprost (free acid) by GC- or LC-MS.
- 產品形式
- 保存建議
- -20
- 其他
- Cayman Chemical
- 注意
-
該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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