- 中文名稱
合成的糖基鞘氨醇
- 英文名字
- Glucosylsphingosine, synthetic
- 供應商
- Matreya
- 產品貨號
- 2086-5
- 產品報價
- ￥詢價/5mg
- 產品說明書
- 點擊查看
- 購買方式
- 銀行轉賬、電匯、支票、現金,在線支付寶及網銀支付,或直接與我們電話聯系400-6800-868
- 產品新聞
- 背景資料
- Glucosylsphingosine is the lyso-derivative of the common glycolipid glucocerebroside. This product is a fully synthetic standard containing only one isomer as opposed to glucosylsphingosine derived from natural sources. Glucosylceramide and glucosylsphingosine are important biological species that are the precursors for many complex glycosphingolipids. These lipids are involved in critical cellular functions such as cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis, and metastasis. One of the most important roles of glucosylsphingosine is as a biomarker for the lysosomal storage disorder Gaucher disease. Gaucher disease is characterized by an accumulation of glucocerebroside due to a deficiency in the enzyme glucocerebrosidase and it has now been found that glucosylsphingosine also accumulates in this disease.1 This accumulation of glucopsychosine contributes to neuronal dysfunction and destruction in patients with neuronopathic Gaucher disease2 and it has been found to be a potent inhibitor of glucocerebrosidase. At least some instances of Gaucher disease also have a deficiency in the activity of glucosylsphingosine beta-glucosidase, the enzyme responsible for cleaving off the glucose of glucopsychosine and glucocerebroside. Like glucocerebroside and galactocerebroside, glucosylsphingosine can increase Ca2 + mobilization from intracellular stores although it uses a different mechanism.3 Conduritol B epoxide (CBE), an inhibitor of beta-glucosidase, and l-phenyl-2-decanoylamino-3-morpholino-l-propanol (PDMP), an inhibitor of glucosylceramide synthase, can be used to create a model of Gaucher disease and consequently an accumulation of glucosylsphingosine.4
- 產品描述
- lyso-Glucocerebroside|1-beta-D-Glucosylsphingosine
- 產品形式
- 該合成的糖基鞘氨醇產品為固體形式
- 保存建議
- 對于本產品，我們推薦使用-20℃藍冰低溫進行運輸。在您收到貨物后，我們建議在-20℃溫度下冷凍保存，溶解使用說明請參考本品說明書。
- 其他
- Matreya LLC是一家脂質生化公司，致力于開發和制造高質量的脂質和生物化學品。Matreya在化學合成以及天然產物提取和純化方面經驗豐富，生產出的產品具有最佳純度。 Matreya產品線包括一系列鞘脂、糖脂、鞘糖脂、脂肪酸和酯、甾醇和維生素E異構體（生育酚和生育三烯酚）。專長是生產高純度鞘氨醇、神經酰胺、硫酸酯、神經節苷脂、酶抑制劑、生育酚和生育三烯酚。是全球提供脂質產品最全的供應商之一。產品涉及生物化學、制藥、微生物學、食品和農業等研究領域。
- 注意
-
該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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