- 中文名稱
YM-53601 (10 mg)
- 英文名字
- YM-53601, 2-[(2E)-2-(1-azabicyclo[2.2.2]oct-3-ylidene)-2-fluoroethoxy]-9H-carbazole, monohydrochloride
- 供應商
- Cayman
- 產品貨號
- 18113-10
- 產品報價
- ￥32928/10 mg
- 產品說明書
- 點擊查看
- 購買方式
- 產品新聞
- 背景資料
- Squalene synthase catalyzes the dimerization of two farnesyl pyrophosphate molecules to form the key cholesterol precursor, squalene.,YM-53601 inhibits squalene synthase activity in rat hepatic microsomes and human Hep-G2 cells with IC50 values of 90 and 79 nM, respectively. Cholesterol biosynthesis is inhibited in rats with an ED50 value of 32 mg/kg YM-53601, causing a reduction in both cholesterol and triglyceride levels in plasma. Cholesterol-reducing HMG-CoA reductase inhibitors, which have little effect on plasma triglyceride levels, are often paired with fibrates, which can have adverse effects, to treat hyperlipidemia. The lipid-lowering properties of compounds such as YM-53601 make squalene synthase inhibition an attractive alternative to the combination HMG-CoA reductase inhibitor/fibrate therapy.,
- 產品描述
- Inhibits squalene synthase activity in rat hepatic microsomes and human Hep-G2 cells (IC50 values of 90 and 79 nM, respectively); inhibits cholesterol biosynthesis in rats reducing both cholesterol and triglyceride levels in plasma
- 產品形式
- 保存建議
- -20
- 其他
- Cayman Chemical
- 注意
-
該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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