中文名稱

15-keto Latanoprost (100 mg)

英文名字

15-keto Latanoprost, 9.alpha.,11.alpha.-dihydroxy-15-oxo-17-phenyl-18,19,2-trinor-prost-5Z-en-1-oic acid, isopropyl ester

供應商

Cayman

產品貨號

16816-100

產品報價

￥38640/100 mg

產品說明書

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背景資料

Latanoprost is an F-series prostaglandin -PG) analog which has been approved for use as an ocular hypotensive drug. Oxidation of the C-15 hydroxyl group without isopropyl ester hydrolysis produces 15-keto latanoprost. 15-keto Latanoprost is a potential metabolite of latanoprost when administered to animals. 15-keto Latanoprost is also one of the common minor impurities found in commercial preparations of the bulk drug compound. Although much less potent that the parent compound latanoprost, 15-keto latanoprost still retains the ability to produce a small but measurable decrease -1 mm Hg) in the intraocular pressure of normal cynomolgus monkeys when administered at a dose of 1 ug/eye. 15-keto Latanoprost is also a miotic in the normal cat eye, causing an 8 mm reduction in pupillary diameter at 5 ug/eye. Again, this is not as potent as many other F-type PGs; for example, PGF2.alpha. will produce this degree of miosis at a dose of less than 1 ug/eye. Products of .beta.-oxidation account for most of the metabolites of latanoprost recovered in plasma and urine. However, 15-keto latanoprost is a minor metabolite, and one which could be enhanced in situations where .beta.-oxidation is reduced.

產品描述

A potential metabolite of latanoprost when administered to animals

產品形式

保存建議

-20

其他

Cayman Chemical

注意

該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。

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