17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F1α (50 mg)-17-TFM-PGF1代理/參數/廠家-生化試劑-艾美捷科技有限公司

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中文名稱: 17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F1α (50 mg)

背景資料: A number of 17-aryl trinor and 16-aryloxy tetranor prostaglandin F2.alpha. derivatives have been approved for the treatment of glaucoma. These ring prostaglandin -PG) analogs have improved efficacy over the PGs with an n-alkyl lower side chain. Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects. 17-trifluoromethylphenyl-13,14-dihydro trinor PGF1.alpha. -17-TFM-PGF1.alpha.) is a typical ring analog reminiscent of the trifluoromethyl-phenoxy ring of Travoprost. The a chain of 17-TFM-PGF1.alpha. is saturated, making this compound a formal member of the one-series PGs. Recent work has shown that in the ring series of analogs, this modification has little impact on FP receptor binding. As an ocular hypotensive agent, it is expected that 17-TFM-PGF1.alpha. would act very much like the free acid of latanoprost.

產品描述: A number of 17-aryl trinor and 16-aryloxy tetranor PGF2.alpha. derivatives have been approved for the treatment of glaucoma.{8941,9341,8839} These ring prostaglandin analogs have improved efficacy over the prostaglandins with an n-alkyl lower side chain. Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects.{9736} 17-TFM-PGF1.alpha. is a typical ring analog reminiscent of the trifluoromethyl-phenoxy ring of Travoprost. The a chain of 17-TFM-PGF1.alpha. is saturated, making this compound a formal member of the one-series PGs. Recent work has shown that in the ring series of analogs, this modification has little impact on FP receptor binding.{9668} As an ocular hypotensive agent, it is expected that 17-TFM-PGF1.alpha. would act very much like the free acid of latanoprost.