TNF-alpha, BioAssay? ELISApot Development Module (Rat) (Cachetin, DIF, TNF, tnfa, tnf-a, TNFSF1A, TNFSF2)-TNF-alpha, BioAssay? ELISApot Development Module (Rat) (Cachetin, DIF, TNF, tnfa, tnf-a, TNFSF1A, TNFSF2)代理/參數/廠家-生化試劑-艾美捷科技有限公司

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中文名稱: TNF-alpha, BioAssay? ELISApot Development Module (Rat) (Cachetin, DIF, TNF, tnfa, tnf-a, TNFSF1A, TNFSF2)

英文名字: TNF-alpha, BioAssay? ELISApot Development Module (Rat) (Cachetin, DIF, TNF, tnfa, tnf-a, TNFSF1A, TNFSF2)

供應商: USBiological

產品貨號: 145770

產品報價: ￥1/1Kit

產品說明書: 點擊查看

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產品描述: Tumor necrosis factor alpha (TNF-alpha), also known as cachectin and TNFSF1A, is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that plays a central role in inflammation, apoptosis, and immune system development. TNF-alpha is produced by a wide variety of immune and epithelial cell types. Human TNF-alpha consists of a 35 amino acid (aa) cytoplasmic domain, a 21aa transmembrane segment, and a 177aa extracellular domain (ECD). Within the ECD, human TNF-alpha shares 97% aa sequence identity with rhesus and 71%-92% with bovine, canine, cotton rat, equine, feline, mouse, porcine, and rat TNF-alpha. The 26kD type 2 transmembrane protein is assembled intracellularly to form a noncovalently linked homotrimer. Ligation of this complex induces reverse signaling that promotes lymphocyte costimulation but diminishes monocyte responsiveness. Cleavage of membrane bound TNF-alpha by TACE/ADAM17 releases a 55kD soluble trimeric form of TNF-alpha. TNF-alpha trimers bind the ubiquitous TNF RI and the hematopoietic cell-restricted TNF RII, both of which are also expressed as homotrimers. TNF-alpha regulates lymphoid tissue development through control of apoptosis. It also promotes inflammatory responses by inducing the activation of vascular endothelial cells and macrophages. TNF-alpha is a key cytokine in the development of several inflammatory disorders. It contributes to the development of type 2 diabetes through its effects on insulin resistance and fatty acid metabolism.Sample Type:Whole cellsIntended Use:BioAssay? ELISpot kits are highly sensitive, microplate-based assays for the detection of cytokine secreting cells. Kits are available for detection and enumeration of a single analyte or two analytes simultaneously. Complete ELISpot kits are ready-to-run and require no assay development or refinement. ELISpot Development Modules contain the basic components required to develop an ELISpot assay. Test Principle:The analyte-specific ELISpot Development Modules contain the components for analyte detection and visualization. Each module contains enough reagents for at least five 96-well microplates.Kit Components:Rat TNF-alpha Capture Antibody Concentrate, lyophilized, 1x vialRat TNF-alpha Detection Antibody Concentrate, lyophilized, 1x vialStorage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C for up to six months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

產品形式: 艾美捷向您提供的TNF-alpha, BioAssay? ELISApot Development Module (Rat) (Cachetin, DIF, TNF, tnfa, tnf-a, TNFSF1A, TNFSF2)產品形式查看產品說明書，建議按照產品說明書進行應用操作。

保存建議: 接收到TNF-alpha, BioAssay? ELISApot Development Module (Rat) (Cachetin, DIF, TNF, tnfa, tnf-a, TNFSF1A, TNFSF2)產品后，置于4°C/-20°C溫度下保存。

其他: Usbiological公司是美國著名的抗體和生化試劑供應商，生產世界上種類最多的抗體，用于Western Blot、免疫沉淀、免疫熒光、免疫組化和流式細胞術等多種檢測方法。Usbiological公司現已擁有超過50,19234種抗體、抗原和生化產品，為科研用戶提供了諸多超值選擇。