- 中文名稱
--)-AS 115 (5 mg)
- 英文名字
- --)-AS 115, 2-fluorophenyl-(2-(((1R,2S)-2-(butoxymethyl)cyclohexyl)methoxy)ethyl)carbamate
- 供應商
- Cayman
- 產品貨號
- 13250-5
- 產品報價
- ￥21070/5 mg
- 產品說明書
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- 購買方式
- 產品新聞
- 背景資料
- KIAA1363 is a 2-acetyl monoacylglyceryl ether -MAGE) hydrolase that is upregulated in aggressive cancers from various tissues. The enzyme catalyzes the hydrolysis of the 2-acetyl MAGE to MAGE and serves as a central enzyme in the PAF and LPA signaling network. AS 115 is a potent and selective inactivator of KIAA1363, displaying an IC50 value of 150 nM when tested as a racemic mixture in the invasive ovarian cancer cell line SK0V-3. Treatment of SKOV-3 cells with 10 uM AS-115 for 4 hours significantly reduced the formation of MAGE, alkyl-lysophosphatidylcholine, and alkyl-lysophosphatidic acid. The activity of the individual enantiomers of AS 115, i.e. -+)-AS 115 and --)-AS 115, has not been determined.
- 產品描述
- A single enantiomer of a potent and selective inactivator of KIAA1363, a MAGE hydrolase an enzyme that is upregulated in addressive cancers from various tissues -IC50 = 150 nM when tested as a racemic mixture in SK0V-3 cells); activity of the individual enantiomers of AS 115, i.e. -+)-AS 115 and --)-AS 115, has not been determined
- 產品形式
- 保存建議
- -20
- 其他
- Cayman Chemical
- 注意
-
該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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