- 中文名稱
MLL1/WARD complex -human recombinant) (2 x 250 ug)
- 英文名字
- KMT2A|Mixed-Lineage Leukemia-1|MLL Core Complex, MLL1/WARD complex -human recombinant)
- 供應商
- Cayman
- 產品貨號
- 10945-2
- 產品報價
- ￥36400/2 x 250 ug
- 產品說明書
- 點擊查看
- 購買方式
- 產品新聞
- 背景資料
- The MLL complex methylates histone 3 at lysine 4 -H3K4) to upregulate transcription. MLL1 is the catalytic subunit and contains the core components WDR5, Ash2L, and RbBP5 -MLL/WAR complex). MLL1 alone exhibits a low basal methyltransferase activity, but is enhanced 300-fold by the addition of the WAR components. A further 2-fold activation has been reported with the addition of DPY-30 -MLL/WARD complex). The MLL core complex colocalizes with RNA Polymerase II on chromosomes and is involved in the transition of paused Pol II to actively-transcribing Pol II. Misregulation of MLL1 by fusion of its non-catalytic N-terminus to any of >50 other proteins leads to leukemia, possibly due to release of paused Pol II at developmentally important sites such as the Hox family of genes. Wild-type MLL1 is targeted to Hox genes through interactions with menin, and is thus important for proper development.,The Cayman MLL1/WARD complex with DPY-30 is supplied as five tubes. Combining the five tubes will result in an equimolar ratio of MLL1, WDR5, Ash2L, and RbBP5. DPY-30, which binds Ash2L as a heterodimer, will be in a two molar excess of the MLL1/WAR components.
- 產品描述
- Source: Active recombinant proteins expressed in E. coli
- 產品形式
- 保存建議
- -80
- 其他
- Cayman Chemical
- 注意
-
該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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