- 中文名稱
Anti-Mouse MD-1
- 英文名字
- Anti-Mouse MD-1
- 供應商
- ReliaTech
- 產品貨號
- 103-M435
- 產品報價
- ￥詢價/100ug
- 產品說明書
- 點擊查看
- 購買方式
- 90%產品中國有現貨庫存。銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868
- 產品新聞
- 背景資料
- MD1 is a secreted glycoprotein that was originally identified as a v-myb-regulated gene from avian myeloleukemia virus-transformed chicken myeloblasts. The mouse homologue of chicken MD1 (also known as lymphocyte antigen 86) was subsequently discovered as a molecule that is associated with RP105, a type I transmembrane glycoprotein with extracellular leucine rich repeats (LRR) typically found in Toll-like receptor (TLR) family members. However, RP105 has a short cytoplasmic tail and lacks the TollIL1 R (TIR) domain that defines the IL1 R/TLR superfamily. RP105 plays an important role in B-cell activation by bacterial lipopolysaccharide (LPS). It is expressed primarily on mature B cells, dendritic cells and macrophages. Mouse MD1 cDNA encodes a 162 amino acid (aa) residue precursor protein with a putative 19 aa signal peptide and two potential Nlinked glycosylation sites. It shares 40% and 66% aa sequence identity with chicken and human MD1 respectively. MD1 is mainly expressed in spleen, and also detectable in liver, brain, thymus, and kidney. MD1 is required for efficient RP105 cell surface expression and function. Cell surface RP105/MD1 complex, in conjunction with TLR4, mediates the innate immune response to LPS in Bcells. Activation of the RP105 complex has been shown to protect against apoptosis, induce Bcell proliferation and upregulate B7.2, a costimulatory molecule. Since MD1 is also expressed in liver and brain where RP105 is absent, it has been speculated that MD1 can also be associated with other LRR-containing molecules, or have additional functions outside the immune system.
- 應用類型
- WB
- 免疫原
- 該Anti-Mouse MD-1的詳細信息查看ReliaTech提供的產品說明書。
- 來源宿主
- 該Anti-Mouse MD-1的詳細信息查看ReliaTech提供的產品說明書。
- 反應性
- 該Anti-Mouse MD-1的詳細信息查看ReliaTech提供的產品說明書。
- 保存建議
- 該Anti-Mouse MD-1的詳細信息查看ReliaTech提供的產品說明書。溶解建議：Centrifuge vial prior to opening. Reconstitute the antibody with 500 μl sterile PBS and the final concentration is 200 μg/ml.
- 其他
- ReliaTech全稱為受體配體技術有限公司 (Receptor Ligand Technologies GmbH)，1999年成立，總部位于德國不倫瑞克，是一家后基因組生物技術公司。ReliaTech主要專注于受體和配體的發現與研究。此外，ReliaTech也開發應用于血管與淋巴管生成研究的相關高品質試劑。目前ReliaTech提供近2800款產品，產品線主要包括重組蛋白(細胞因子、生長因子、可溶性受體)、抗體、ELISA試劑盒等。
- 注意
-
該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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