- 中文名稱
Anti-Mouse Dectin-2
- 英文名字
- Anti-Mouse Dectin-2
- 供應商
- ReliaTech
- 產品貨號
- 103-M371
- 產品報價
- ￥詢價/100ug
- 產品說明書
- 點擊查看
- 購買方式
- 90%產品中國有現貨庫存。銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868
- 產品新聞
- 背景資料
- Dectin2α or Dectin2, also known as CLEC6A, CLECSF10, and NKCL, belongs to the Ctype lectin family of transmembrane immune regulatory glycoproteins. Dectin 2α, CLEC4A/DCIR, CLEC4B/DCAR, CLEC4C/DLEC, CLEC4D/MCL, and CLEC4E/mincle constitute a subgroup of these molecules that exhibit approximately 40% amino acid (aa) sequence identity in their extracellular domains (ECD) and have a conserved cysteine spacing in their carbohydrate recognition domains (CRD). Mature mouse Dectin2α consists of a short cytoplasmic tail, a transmembrane segment, and an ECD with a stalk region and one CRD. Alternate splicing leads to partial deletion of the transmembrane segment and stalk ( β isoform) or a portion of the CRD (γ isoform). The full length Dectin2α isoform is a 27 kDa molecule that is primarily expressed on the surface of tissue macrophages and their precursors. The CRD of Dectin2α contains an EPN motif which is characteristic of calciumdependent mannosebinding lectins. Dectin2α selectively interacts with high mannose structures in the Man9GlcNAc2 configuration. It mediates the recognition of a variety of microorganisms, particularly the filamentous forms of yeast and fungii. The short cytoplasmic tail does not contain signaling motifs but mediates association with the ITAMcontaining Fc receptor γ subunit in macrophages. Ligation of Dectin2α induces tyrosine phosphorylation of the γ subunit, activation of NFκB, and enhanced release of TNFα and IL1ra. Macrophage Dectin2α is upregulated in vivo by inflammatory stimuli and UVB irradiation. It mediates the breaking of UVinduced tolerance by interacting with CD4+CD25+ regulatory T cells which then induce dendritic cells to release IL4, IL10, and TGFβ. Within the ECD, mouse Dectin2α shares 71% aa sequence identity with human and bovine Dectin2.
- 應用類型
- WB
- 免疫原
- 該Anti-Mouse Dectin-2的詳細信息查看ReliaTech提供的產品說明書。
- 來源宿主
- 該Anti-Mouse Dectin-2的詳細信息查看ReliaTech提供的產品說明書。
- 反應性
- 該Anti-Mouse Dectin-2的詳細信息查看ReliaTech提供的產品說明書。
- 保存建議
- 該Anti-Mouse Dectin-2的詳細信息查看ReliaTech提供的產品說明書。溶解建議：Centrifuge vial prior to opening. Reconstitute the antibody with 500 μl sterile PBS and the final concentration is 200 μg/ml.
- 其他
- ReliaTech全稱為受體配體技術有限公司 (Receptor Ligand Technologies GmbH)，1999年成立，總部位于德國不倫瑞克，是一家后基因組生物技術公司。ReliaTech主要專注于受體和配體的發現與研究。此外，ReliaTech也開發應用于血管與淋巴管生成研究的相關高品質試劑。目前ReliaTech提供近2800款產品，產品線主要包括重組蛋白(細胞因子、生長因子、可溶性受體)、抗體、ELISA試劑盒等。
- 注意
-
該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
-
