- 中文名稱
Anti-Mouse Trk-B
- 英文名字
- Anti-Mouse Trk-B
- 供應商
- ReliaTech
- 產品貨號
- 103-M196
- 產品報價
- ￥詢價/100ug
- 產品說明書
- 點擊查看
- 購買方式
- 90%產品中國有現貨庫存。銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868
- 產品新聞
- 背景資料
- The neurotrophins, including NGF, BDNF, NT3 and NT4/5, constitute a group of structurally related, secreted proteins that play an important role in the development and function of the nervous system. The biological activities of the neurotrophins are mediated by binding to and activating two unrelated receptor types: the p75 neurotrophin receptor (p75NTR) and the Trk family of receptor tyrosine kinases. p75NTR is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and has been designated TNFRSF16. It binds all neurotrophins with low affinity to transduce cellular signaling pathways that synergize with or antagonize those activated by the Trk receptors. Three Trk family proteins, TrkA, TrkB, and TrkC, exhibiting different ligand specificities, have been identified. TrkA binds NGF and NT3, TrkB binds BDNF, NT3 and NT4/5, and TrkC only binds NT3. All Trk family proteins share a conserved, complex subdomain organization consisting of a signal peptide, two cysteinerich domains, a cluster of three leucinerich motifs, and two immunoglobulinlike domains in the extracellular region, as well as an intracellular region that contains the tyrosine kinase domain. Natural splice variants of the different Trks, lacking the first cysteinerich domain, the first and second or all three of the leucine-rich motifs, or the tyrosine kinase domain, have been described. At the protein sequence level, human and mouse TrkB show 94% amino acid sequence identity. The proteins also exhibit crossspecies activity. The primary location of TrkB expression is in the central and peripheral nervous systems. Low level TrkB expression has also been observed in a wide variety of tissues outside the nervous system.
- 應用類型
- WB, IHC (P)
- 免疫原
- 該Anti-Mouse Trk-B的詳細信息查看ReliaTech提供的產品說明書。
- 來源宿主
- 該Anti-Mouse Trk-B的詳細信息查看ReliaTech提供的產品說明書。
- 反應性
- 該Anti-Mouse Trk-B的詳細信息查看ReliaTech提供的產品說明書。
- 保存建議
- 該Anti-Mouse Trk-B的詳細信息查看ReliaTech提供的產品說明書。溶解建議：Centrifuge vial prior to opening. Reconstitute the antibody with 500 μl sterile PBS and the final concentration is 200 μg/ml.
- 其他
- ReliaTech全稱為受體配體技術有限公司 (Receptor Ligand Technologies GmbH)，1999年成立，總部位于德國不倫瑞克，是一家后基因組生物技術公司。ReliaTech主要專注于受體和配體的發現與研究。此外，ReliaTech也開發應用于血管與淋巴管生成研究的相關高品質試劑。目前ReliaTech提供近2800款產品，產品線主要包括重組蛋白(細胞因子、生長因子、可溶性受體)、抗體、ELISA試劑盒等。
- 注意
-
該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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