- 中文名稱
Anti-Human EGFR/p110, soluble
- 英文名字
- Anti-Human EGFR/p110, soluble
- 供應商
- ReliaTech
- 產品貨號
- 102-PA12S
- 產品報價
- ￥詢價/100ug
- 產品說明書
- 點擊查看
- 購買方式
- 90%產品中國有現貨庫存。銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868
- 產品新聞
- 背景資料
- The epidermal growth factor receptor (EGFR) subfamily of receptor tyrosine kinases comprises four members: EGFR (also known as HER1, ErbB1 or ErbB), ErbB2 (Neu, HER-2), ErbB3 (HER-3), and ErbB4 (HER-4). All family members are type I transmembrane glycoprotein that has an extracellular domain which contains two cysteine-rich domains separated by a spacer region that is involved in ligand-binding, and a cytoplasmic domain which has a membrane-proximal tyrosine kinase domain and a C-terminal tail with multiple tyrosine autophosphorylation sites. Previously the cloning and expression of a 3 kb alternative EGFR transcript which encodes a 110 kDa form of the receptor (sEGFR/p110) was reported. This receptor isoform is identical to the extracellular region of the full-length 170 kDa EGFR through amino acid 603; in addition, p110 sEGFR contains 78 unique carboxy-terminal amino acids. The sEGFR/p110 is associated with the cell membrane and can be released, allowing detection in human serum and plasma. The existence of this circulating sEGFR isoform stimulated investigation of its role as a potential circulating biomarker. Several studies suggest that alterations in sEGFR levels may be useful in cancer diagnosis and in monitoring disease recurrence and outcome, especially in patients with ovarian or breast cancer. The new polyclonal antibody may be useful in determining the expression, localization, and function of sEGFR/p110, and importantly will allow to distinguish between the expression of this receptor isoform and full length EGF receptor.
- 應用類型
- WB, IHC
- 免疫原
- 該Anti-Human EGFR/p110, soluble的詳細信息查看ReliaTech提供的產品說明書。
- 來源宿主
- Rabbit
- 反應性
- 該Anti-Human EGFR/p110, soluble的詳細信息查看ReliaTech提供的產品說明書。
- 保存建議
- 該Anti-Human EGFR/p110, soluble的詳細信息查看ReliaTech提供的產品說明書。
- 其他
- ReliaTech全稱為受體配體技術有限公司 (Receptor Ligand Technologies GmbH)，1999年成立，總部位于德國不倫瑞克，是一家后基因組生物技術公司。ReliaTech主要專注于受體和配體的發現與研究。此外，ReliaTech也開發應用于血管與淋巴管生成研究的相關高品質試劑。目前ReliaTech提供近2800款產品，產品線主要包括重組蛋白(細胞因子、生長因子、可溶性受體)、抗體、ELISA試劑盒等。
- 注意
-
該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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