- 中文名稱
Anti-Human FAS Ligand, soluble
- 英文名字
- Anti-Human FAS Ligand, soluble
- 供應商
- ReliaTech
- 產品貨號
- 102-P120G
- 產品報價
- ￥詢價/100ug
- 產品說明書
- 點擊查看
- 購買方式
- 90%產品中國有現貨庫存。銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868
- 產品新聞
- 背景資料
- Fas Ligand (FasL), also known as CD178, CD95L, or TNFSF6, is a 40 kDa type II transmembrane member of the TNF superfamily of proteins. Its ability to induce apoptosis in target cells plays an important role in the development, homeostasis, and function of the immune system. Mature human Fas Ligand consists of a 179 amino acid (aa) extracellular domain (ECD), a 22 aa transmembrane segment, and a 80 aa cytoplasmic domain. Within the ECD, human Fas Ligand shares 81% and 78% aa sequence identity with mouse and rat Fas Ligand, respectively. Both mouse and human Fas Ligand are active on mouse and human cells. Fas Ligand is expressed on the cell surface as a nondisulfidelinked homotrimer on activated CD4+ Th1 cells, CD8+ cytotoxic T cells, and NK cells. Fas Ligand binding to Fas/CD95 on an adjacent cell triggers apoptosis in the Fas expressing cell. Fas Ligand also binds DcR3 which is a soluble decoy receptor that interferes with Fas Ligandinduced apoptosis. Fas Ligand can be released from the cell surface by metalloproteinases as a 26 kDa soluble molecule which remains trimeric. Shed Fas Ligand retains the ability to bind Fas, although its ability to trigger apoptosis is dramatically reduced. In the absence of TGFβ, however, Fas Ligand/Fas interactions instead promote neutrophilmediated inflammatory responses. Fas Ligand itself transmits reverse signals that costimulate the proliferation of freshly antigenstimulated T cells. Fas Ligandinduced apoptosis plays a central role in the development of immune tolerance and the maintance of immune privileged sites. This function is exploited by tumor cells which evade immune surveillance by upregulating Fas Ligand to kill tumor infiltrating lymphocytes. In gld mice, a Fas Ligand point mutation is the cause of severe lympho-proliferation and systemic autoimmunity.
- 應用類型
- ELISA, WB, N
- 免疫原
- 該Anti-Human FAS Ligand, soluble的詳細信息查看ReliaTech提供的產品說明書。
- 來源宿主
- Goat
- 反應性
- 該Anti-Human FAS Ligand, soluble的詳細信息查看ReliaTech提供的產品說明書。
- 保存建議
- 該Anti-Human FAS Ligand, soluble的詳細信息查看ReliaTech提供的產品說明書。溶解建議：Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
- 其他
- ReliaTech全稱為受體配體技術有限公司 (Receptor Ligand Technologies GmbH)，1999年成立，總部位于德國不倫瑞克，是一家后基因組生物技術公司。ReliaTech主要專注于受體和配體的發現與研究。此外，ReliaTech也開發應用于血管與淋巴管生成研究的相關高品質試劑。目前ReliaTech提供近2800款產品，產品線主要包括重組蛋白(細胞因子、生長因子、可溶性受體)、抗體、ELISA試劑盒等。
- 注意
-
該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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