Members of the UNC5H family are best known as receptors for the axon guidance molecule netrin. Structurally, UNC5Hs have two Ig and two thrombospondin type 1 domains in their extracellular region, and a conserved ZU-5 domain, a deleted in colorectal cancer (DCC)-binding domain, and a C-terminal death domain in their cytoplasmic region. In general, they mediate the chemorepulsive effects of netrin, while the other netrin receptor subtype, DCC, mediates attraction. Members of the UNC5H family have also been implicated as tumor suppressors and regulators of apoptosis.
應用類型
WB, IHC (P)
免疫原
該Anti-Human UNC5H3的詳細信息查看ReliaTech提供的產品說明書。
來源宿主
該Anti-Human UNC5H3的詳細信息查看ReliaTech提供的產品說明書。
反應性
該Anti-Human UNC5H3的詳細信息查看ReliaTech提供的產品說明書。
保存建議
該Anti-Human UNC5H3的詳細信息查看ReliaTech提供的產品說明書。溶解建議：Centrifuge vial prior to opening. Reconstitute the antibody with 500 μl sterile PBS and the final concentration is 200 μg/ml.
