- 中文名稱
Anti-Human FGF-16
- 英文名字
- Anti-Human FGF-16
- 供應商
- ReliaTech
- 產品貨號
- 101-M404
- 產品報價
- ￥詢價/100ug
- 產品說明書
- 點擊查看
- 購買方式
- 90%產品中國有現貨庫存。銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868
- 產品新聞
- 背景資料
- Fibroblast growth factor 16 (FGF16) belongs to the large FGF family which has at least 23 members. All FGF family members are heparinbinding growth factors with a core 120 amino acid (aa) FGF domain that allows for a common tertiary structure. FGFs are expressed during embryonic development and in restricted adult tissues. They act on cells of mesodermal and neuroectodermal origin to regulate diverse physiologic functions including angiogenesis, cell growth, pattern formation, embryonic development, metabolic regulation, cell migration, neurotrophic effects and tissue repair. Signaling receptors for FGFs are type I transmembrane receptor tyrosine kinases belonging to the immunoglobulin (Ig) superfamily. Four distinct but related classes of FGF receptors, FGF R1, 2, 3, and 4, exist. Through alternative splicing, multiple isoforms for FGF R1, 2 and 3, with distinct ligand recognition profiles, are also generated. Human FGF16 cDNA predicts a 207 aa precursor protein with one N-linked glycosylation site. FGF16 lacks a typical signal peptide but is efficiently generated by mechanisms other than the classical protein secretion pathway. Among FGF family members, FGF16 is most similar to FGF9, sharing 73% aa sequence homology. Human FGF16 shares 99% and 98.6% aa sequence identity with the mouse and rat FGF16, respectively. In rat embryos, FGF16 message is expressed predominantly in brown adipocytes. In adult animals, it is localized primarily in heart tissue. FGF16 binds to and activates FGF receptor 4. FGF16 induces proliferation of primary adipocytes and oligodendrocytes in vitro and stimulates liver weight increase in vivo. The expression pattern of FGF16 and its effect on adipocyte proliferation suggest a role for this protein on the proliferation of embryonic brown adipose tissue.
- 應用類型
- WB
- 免疫原
- 該Anti-Human FGF-16的詳細信息查看ReliaTech提供的產品說明書。
- 來源宿主
- 該Anti-Human FGF-16的詳細信息查看ReliaTech提供的產品說明書。
- 反應性
- 該Anti-Human FGF-16的詳細信息查看ReliaTech提供的產品說明書。
- 保存建議
- 該Anti-Human FGF-16的詳細信息查看ReliaTech提供的產品說明書。溶解建議：Centrifuge vial prior to opening. Reconstitute the antibody with 500 μl sterile PBS and the final concentration is 200 μg/ml.
- 其他
- ReliaTech全稱為受體配體技術有限公司 (Receptor Ligand Technologies GmbH)，1999年成立，總部位于德國不倫瑞克，是一家后基因組生物技術公司。ReliaTech主要專注于受體和配體的發現與研究。此外，ReliaTech也開發應用于血管與淋巴管生成研究的相關高品質試劑。目前ReliaTech提供近2800款產品，產品線主要包括重組蛋白(細胞因子、生長因子、可溶性受體)、抗體、ELISA試劑盒等。
- 注意
-
該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
-
