Anti-Human Desmoglein-3-Anti-Human Desmoglein-3代理/參數/廠家-一抗-艾美捷科技有限公司

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背景資料: Desmoglein3, also known as pemphigus vulgaris antigen (PVA), is a 130 kDa transmembrane glycoprotein that belongs to the cadherin family of calcium dependent adhesion molecules. Human Desmoglein3 is synthesized with a 26 amino acid (aa) propeptide. The mature protein consists of a 566 aa extracellular domain (ECD) that contains four cadherinlike domains, a 25 aa transmembrane segment, and a 359 aa cytoplasmic domain. Within the ECD, human Desmoglein3 shares 78% aa sequence identity with mouse and rat Desmoglein3. It shares 44%, 47%, and 56% aa sequence identity with Desmoglein1, 2, and 4 respectively. Desmoglein3 is one of the principal components of desmosomes which form adhesive contacts between epithelial cells. It is expressed in the basal and suprabasal layers of stratified epithelia in many tissues. During apoptosis, Desmoglein3 is cleaved by caspases, plus MMP2, and MMP9 at sites within the cytoplasmic and extracellular regions, resulting in shortened transmembrane forms and a soluble 75 kDa ECD fragment. The downregulation of Desmoglein3 in oral squamous cell carcinoma correlates with metastatic potential. Desmoglein3 is the target of autoantibodies in pemphigus vulgaris, a blistering skin disorder with compromised interkeratinocyte adhesion. Binding of these antibodies triggers Desmoglein3 internalization and degradation by keratinocytes.

保存建議: 該Anti-Human Desmoglein-3的詳細信息查看ReliaTech提供的產品說明書。溶解建議：Centrifuge vial prior to opening. Reconstitute the antibody with 500 μl sterile PBS and the final concentration is 200 μg/ml.

其他: ReliaTech全稱為受體配體技術有限公司 (Receptor Ligand Technologies GmbH)，1999年成立，總部位于德國不倫瑞克，是一家后基因組生物技術公司。ReliaTech主要專注于受體和配體的發現與研究。此外，ReliaTech也開發應用于血管與淋巴管生成研究的相關高品質試劑。目前ReliaTech提供近2800款產品，產品線主要包括重組蛋白(細胞因子、生長因子、可溶性受體)、抗體、ELISA試劑盒等。