Desmoglein1 is one of three members of the desmoglein subfamily of calcium-dependent cadherin cell adhesion molecules. Together with desmocollins, another subfamily within the cadherin superfamily, the desmoglein isoforms form the adhesive components of desmosomes, the cel-lcell adhesive structures that are found in epithelial cells. Human Desmoglein1 is a type I transmembrane glycoprotein of 1049 amino acid (aa) residues with a 23 aa signal peptide and a 26 aa propeptide. It differs from other classic cadherins by having four instead of five cadherin repeat domains in its extracellular region, and a much larger cytoplasmic region containing five desmoglein repeat domains which share homology with the cadherin repeats. Instead of having the HAV adhesion motif found in type I cadherins, Desmoglein1 has R/YAL as the adhesion motif on its amino-terminal cadherin repeat. The cytoplasmic tail of Desmoglein 1 interacts with desmoplakins, plakoglobin and plakophilins. In turn, these proteins link the Desmoglein1 with the intermediate filaments. Desmoglein1 has been shown to be important in establishing cellcell adhesion and function in the epidermis. In the autoimmune skin disease pemphigus foliaceus, autoantibodies to Desmoglein1 can cause the loss of keratinocyte adhesion resulting in blisters.
應用類型
WB
免疫原
該Anti-Human Desmoglein-1的詳細信息查看ReliaTech提供的產品說明書。
來源宿主
該Anti-Human Desmoglein-1的詳細信息查看ReliaTech提供的產品說明書。
反應性
該Anti-Human Desmoglein-1的詳細信息查看ReliaTech提供的產品說明書。
保存建議
該Anti-Human Desmoglein-1的詳細信息查看ReliaTech提供的產品說明書。溶解建議：Centrifuge vial prior to opening. Reconstitute the antibody with 500 μl sterile PBS and the final concentration is 200 μg/ml.
