CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. CTLA-4 is up-regulated rapidly following T cell activation and CD28 ligation. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28.
應用類型
WB
免疫原
該Anti-Human CTLA-4的詳細信息查看ReliaTech提供的產品說明書。
來源宿主
該Anti-Human CTLA-4的詳細信息查看ReliaTech提供的產品說明書。
反應性
該Anti-Human CTLA-4的詳細信息查看ReliaTech提供的產品說明書。
保存建議
該Anti-Human CTLA-4的詳細信息查看ReliaTech提供的產品說明書。溶解建議：Centrifuge vial prior to opening. Reconstitute the antibody with 500 μl sterile PBS and the final concentration is 200 μg/ml.
