- 中文名稱
Anti-Human BMP-3
- 英文名字
- Anti-Human BMP-3
- 供應商
- ReliaTech
- 產品貨號
- 101-M234
- 產品報價
- ￥詢價/100ug
- 產品說明書
- 點擊查看
- 購買方式
- 90%產品中國有現貨庫存。銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868
- 產品新聞
- 背景資料
- BMP3, also known as osteogenin, the most abundant BMP in adult bone, is one of at least 15 structurally and functionally related BMPs, which are members of the TGFβ superfamily (13). BMPs were originally identified as protein regulators of cartilage and bone formation. They have since been shown to be involved in embryogenesis and morphogenesis of various tissues and organs. BMPs also regulate the growth, differentiation, chemotaxis, and apoptosis of various cell types. Similar to most other TGFβfamily proteins, BMPs are highly conserved across animal species. At the amino acid sequence level, mature human and rat BMP3 are 98% identical. BMP3 is synthesized as a large precursor protein that is cleaved at the dibasic cleavage site (RXXR) to release the carboxyterminal domain. Biologically active BMP3 is a disulfidelinked homodimer of the carboxyterminal 110 amino acid residues that contains the characteristic seven conserved cysteine residues involved in the formation of the cysteine knot and the single interchain disulfide bond (4). The role of BMP3 in bone is contradictory since, unlike osteogenin purified from bone, recombinant BMP3 has not shown osteogenic function (5). Several studies indicate that BMP3 is an inhibitor of osteogenic BMPs. BMP3 dorsalizes Xenopus embryos, the opposite effect of BMP2 or 4, which cause ventralization. BMP3 inhibits alkaline phosphatase production and induction of osteoblastic target genes in undifferentiated mesenchymal and osteogenic cell lines that have been treated with BMP2. BMP3 also induces the expression of TGFβ/ activin responsive genes, but not BMPresponsive genes.
- 應用類型
- WB
- 免疫原
- 該Anti-Human BMP-3的詳細信息查看ReliaTech提供的產品說明書。
- 來源宿主
- 該Anti-Human BMP-3的詳細信息查看ReliaTech提供的產品說明書。
- 反應性
- 該Anti-Human BMP-3的詳細信息查看ReliaTech提供的產品說明書。
- 保存建議
- 該Anti-Human BMP-3的詳細信息查看ReliaTech提供的產品說明書。溶解建議：Centrifuge vial prior to opening. Reconstitute the antibody with 500 μl sterile PBS and the final concentration is 200 μg/ml.
- 其他
- ReliaTech全稱為受體配體技術有限公司 (Receptor Ligand Technologies GmbH)，1999年成立，總部位于德國不倫瑞克，是一家后基因組生物技術公司。ReliaTech主要專注于受體和配體的發現與研究。此外，ReliaTech也開發應用于血管與淋巴管生成研究的相關高品質試劑。目前ReliaTech提供近2800款產品，產品線主要包括重組蛋白(細胞因子、生長因子、可溶性受體)、抗體、ELISA試劑盒等。
- 注意
-
該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
-
