- 中文名稱
Farnesyl Thiosalicylic Acid (1 mg)
- 英文名字
- FTS|Salirasib, Farnesyl Thiosalicylic Acid, 2-[[(2E,6E)-3,7,11-trimethyl-2,6,1-dodecatrien-1-yl]thio]-benzoic acid
- 供應商
- Cayman
- 產品貨號
- 10010501-1
- 產品報價
- ￥84/1 mg
- 產品說明書
- 點擊查看
- 購買方式
- 產品新聞
- 背景資料
- Association of Ras protein with the inner surface of the plasma membrane is required for Ras signaling activity. Farnesyl thiosalicylic acid -FTS) is an inhibitor of Ras-mediated signaling that functions by dislodging Ras from the cell membrane thereby rendering it susceptible to proteolytic degradation. FTS inhibits the growth of human Ha-ras-transformed Rat1 fibroblasts with an IC50 value of 7.5 uM. It does not inhibit Ras farnesylation in vitro and although FTS does inhibit prenylated protein methyltransferase -PPMTase) in cell-free systems with a Ki value of 2.6 uM, it is relatively ineffective at inhibiting methylation in whole cells. Treatment of chow-fed ApoE-deficient mice with 5 mg/kg FTS three times per week for six weeks reduces early atherosclerotic lesion development by 52% compared to controls.
- 產品描述
- An inhibitor of Ras-mediated signaling that functions by dislodging Ras from the cell membrane thereby rendering it susceptible to proteolytic degradation; inhibits the growth of human Ha-ras-transformed Rat1 fibroblasts with an IC50 value of 7.5 uM
- 產品形式
- 保存建議
- -20
- 其他
- Cayman Chemical
- 注意
-
該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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