- 中文名稱
Lovastatin (25 mg)
- 英文名字
- Lovastatin, 2-methyl-1S,2,3R,7S,8S,8aR-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, butanoic acid
- 供應商
- Cayman
- 產品貨號
- 10010338-25
- 產品報價
- ￥1008/25 mg
- 產品說明書
- 點擊查看
- 購買方式
- 產品新聞
- 背景資料
- Hydroxymethylglutaryl-coenzyme A -HMG-CoA) reductase is the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the statin class of cholesterol-lowering drugs. Lovastatin is an HMG-CoA reductase inhibitor that was initially isolated from Aspergillus terreus. Marketed as MevinolinTM, MevacorTM, and under several other trade names, Lovastatin was the first HMG-CoA reductase inhibitor to be used in the treatment of hypercholesterolemia. It is a competitive inhibitor of HMG-CoA reductase with a Ki value of 0.6 nM for the open ring, hydroxy acid form of the molecule. During a three week study in dogs, a dose of 8 mg/kg per day resulted in a 29% reduction in plasma cholesterol. Lovastatin also suppresses TNF-induced NF-.kappa.B activation -IC50 ~ 15 uM), which potentiates apoptosis in human myeloid leukemia cells and thus, maybe useful in treating cancer.
- 產品描述
- A potent, competitive inhibitor of HMG-CoA reductase -Ki = 0.6 nM)
- 產品形式
- 保存建議
- -20
- 其他
- Cayman Chemical
- 注意
-
該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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