- 中文名稱
ChREBPDBD WB即用型對照 (1 ea)
- 英文名字
- ChREBP DBD Western Ready Control (1 ea)
- 供應商
- Cayman
- 產品貨號
- 10009753-1
- 產品報價
- ￥714/1 ea
- 產品說明書
- 點擊查看
- 購買方式
- 產品新聞
- 背景資料
- The Carbohydrate Response Element-binding Protein -ChREBP) is a member of the basic helix-loop-helix leucine zipper transcription factor family. Under conditions of low glucose, ChREBP is phosphorylated which sequesters the transcription factor in the cytoplasm. Under conditions of elevated glucose, one of its metabolites, xylulose 5-phosphate activates Protein Phosphatase 2A -PP2A) which dephosphorylates ChREBP at Ser196. Dephosphorylated -Ser196) ChREBP translocates into the nucleus where it is further dephosphorylated at Thr666 by PP2A. The second dephosphorylation allows ChREBP to bind to the carbohydrate response element -CRE) within the promoter of the L-type pyruvate kinase -L-PK) gene, as well as a subset of lipogenic enzymes. Activation of ChREBP by high glucose in the liver occurs independently of insulin concentrations. The inactivation of ChREBP has been proposed as a potential method for reducing obesity and also improving glucose tolerance.
- 序列
- 來源宿主
- 溶解建議
- 保存建議
- -20
- 其他
- Cayman Chemical
- 注意
-
該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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