- 中文名稱
抗黑皮質素-4受體多克隆抗體
- 英文名字
- Melanocortin-4 Receptor Polyclonal Antibody
- 供應商
- Cayman
- 產品貨號
- 10006355-500
- 產品報價
- ￥3206/500 μl
- 產品說明書
- 點擊查看
- 購買方式
- 產品新聞
- 背景資料
- Melanocortins are known to exert a broad array of physiological actions including melanogenesis, steroidogenesis, sexual function and inflammation, as well as appetite regulation and energy homeostasis . These actions are mediated -differentially or concurrently) in part by a family of G-protein coupled receptors, the melanocortin receptors 1-5 -MC1R-MC5R). Melanocortin-4 receptor -MC4R) was first cloned in 1993 with transcripts expressed primarily in the brain. Genetic studies of mice and humans have established a critical role of MC4R in appetite regulation. Heterozygous mutations in MC4R account for 1-6% of severe cases of human obesity. Thus, MC4R has been a prime target for therapeutic intervention in obesity. All known mammalian MC4Rs are 332 amino acids in length with an estimated molecular weight of 37 kDa. The protein is heavily glycosylated and appears at multiple positions on SDS-PAGE. Cayman s MC4R polyclonal antibody mainly detects an unglycosylated protein at 37 kDa and a glycosylated protein at 55 kDa.
- 應用類型
- WB and IHC -formalin-fixed paraffin-embedded sections); other applications not tested
- 免疫原
- mouse melanocortin-4 receptor amino acids 21-33 -YGLHSNASESLGK)
- 來源宿主
- rabbit
- 反應性
- Human MC4R+|Mouse MC4R+|Rat MC4R+
- 保存建議
- 其他
- Cayman Chemical
- 注意
-
該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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