- 中文名稱
PDM 2 (500 mg)
- 英文名字
- PDM 2, 1,3-dichloro-5-[(1E)-2-(4-chlorophenyl)ethenyl]-benzene
- 供應商
- Cayman
- 產品貨號
- 10006342-500
- 產品報價
- ￥16170/500 mg
- 產品說明書
- 點擊查看
- 購買方式
- 產品新聞
- 背景資料
- The aryl hydrocarbon receptor -AhR) is a ligand-dependent intracellular transcription factor whose ligands include some of the most infamous xenobiotics, including dioxin, benzo[a]pyrene, and numerous polyaromatics from soot and coal tar. PDM 2 is an analog of resveratrol acting as a potent and selective AhR antagonist, with a Ki of 1.2 nM. PDM 2 is inactive as a ligand for the estrogen receptor even at 100 uM. As AhR knockout mice are insensitive to the carcinogenic effects of classical AhR ligands, PDM 2 is a potential therapeutic for the treatment for dioxin and other aryl hydrocarbon poisonings.
- 產品描述
- The aryl hydrocarbon receptor -AhR) is a ligand-dependent intracellular transcription factor whose ligands include some of the most infamous xenobiotics, including dioxin, benzo[a]pyrene, and numerous polyaromatics from soot and coal tar.{12907} PDM 2 is an analog of resveratrol acting as a potent and selective AhR antagonist, with a Ki of 1.2 nM.{12475} PDM 2 is inactive as a ligand for the estrogen receptor even at 100 uM. As AhR knockout mice are insensitive to the carcinogenic effects of classical AhR ligands, PDM 2 is a potential therapeutic for the treatment for dioxin and other aryl hydrocarbon poisonings.
- 產品形式
- 保存建議
- -20
- 其他
- Cayman Chemical
- 注意
-
該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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