- 中文名稱
Caylin-1 (50 mg)
- 英文名字
- Caylin-1, 4-[4,5-bis(3,4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carboxyl]-piperazin-2-one
- 供應商
- Cayman
- 產品貨號
- 10004985-50
- 產品報價
- ￥24500/50 mg
- 產品說明書
- 點擊查看
- 購買方式
- 產品新聞
- 背景資料
- Nutlin-3 is an activator of p53 that functions by inhibiting the interaction of p53 with MDM2, a negative regulator of p53 activity. Caylin-1 is a nutlin-3 analog which contains chlorine substituents at the 3 and 4 positions on two of the phenyl rings rather than a single 4-chloro as seen in nutlin-3. At high concentrations, caylin-1 inhibits the growth of HCT-116 cells with an IC50 value of approximately 7 uM, making it about 7-fold less potent than nutlin-3 in the same assay. Interestingly, at concentrations at or below 1 uM, caylin-1 promotes the growth of HCT-116 cells approximately 20% compared to untreated cells. The mechanism of the growth promoting properties of caylin-1 have not yet been elucidated.
- 產品描述
- A nutlin-3 analog; inhibits the growth of HCT-116 cells at high concentrations -IC50 = ~7 uM); promotes the growth of HCT-116 cells ~20% at concentrations at or below 1 uM
- 產品形式
- 保存建議
- -20
- 其他
- Cayman Chemical
- 注意
-
該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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