- 中文名稱
Leptomycin B (50 ug)
- 英文名字
- Elactocin|LMB|Mantuamycin|NSC 364372, Leptomycin B, 19-[(2S,3S)-3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-hydroxy-3,5S,7S,9R,11,15R,hexamethyl-8-oxo-2E,1E,12E,16Z,18E-nonadecapentaenoic acid
- 供應商
- Cayman
- 產品貨號
- 10004976-50
- 產品報價
- ￥24304/50 ug
- 產品說明書
- 點擊查看
- 購買方式
- 產品新聞
- 背景資料
- Leptomycin B is a potent inhibitor of the nuclear export of proteins. It directly blocks the interaction of CRM1 -exportin 1) with nuclear export signals -NES), preventing the export of a broad range of proteins. Leptomycin B will also indirectly inhibit the export of mRNA from the nucleus by blocking the nuclear export of mRNA-binding proteins -export factors). By blocking the nuclear export of p53, leptomycin B prevents entry of human normal fibroblasts into the S phase of the cell cycle, thus inhibiting proliferation. Leptomycin B was originally identified as an antifungal agent and is isolated from Streptomyces sp..
- 產品描述
- A potent anti-fungal antibiotic that can directly block nuclear transport by inhibiting the action of CRM1; inhibits nuclear export of HIV-1 Rev -IC50 = 0.53)
- 產品形式
- 保存建議
- -20
- 其他
- Cayman Chemical
- 注意
-
該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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