Click Chemistry Tools/艾美捷DBCO-PEG4-NHS酯特異性且高效方案

DBCO-PEG4-NHS酯在pH 7-9的條件下能特異性且高效地與一級胺（例如，賴氨酸殘基的側鏈或氨基硅烷包覆的表面）反應形成共價鍵。親水性的聚乙二醇（PEG）間隔臂賦予了水溶性，并提供了一個長而靈活的連接，這極小化了與含有疊氮的互補分子連接時的立體阻礙。

艾美捷Click Chemistry Tools DBCO-PEG4-NHS酯 #CCT-A134規格：

單位規格 10毫克，4×2毫克，25毫克，100毫克，500毫克

分子量 649.68

化學成分 C34H39N3O10

CAS號 1427004-19-0

溶解性 DMSO、DMF、二氯甲烷（DCM）、四氫呋喃（THF）、氯仿

純度 >95%（高效液相色譜法，HPLC）

外觀 黃色至微橙色油狀物

儲存條件 -20攝氏度。保持干燥

運輸條件 常溫

Click Chemistry Tools DBCO-PEG4-NHS酯文獻參考：

Wang X., et al. (2021). Equipping Natural Killer Cells with Cetuximab through Metabolic Glycoengineering and Bioorthogonal Reaction for Targeted Treatment of KRAS Mutant Colorectal Cancer. ACS Chem. Biol., 16 (4), 724-730. [PubMed]

Wiener, J., et al. (2020). Preparation of single- and double-oligonucleotide antibody conjugates and their application for protein analytics. Sci Rep., 10 (1), 1457. [PubMed]

Ahn, S.H., et al. (2020). Site-Specific 89Zr- and 111In-Radiolabeling and In Vivo Evaluation of Glycan-free Antibodies by Azide–Alkyne Cycloaddition with a Non-natural Amino Acid. Bioconjugate Chem., 31(4), 1177-87. [PubMed]

Pack, J., et al. (2020). Site-Specific Antibody Conjugation Strategy to Functionalize Virus-Based Nanoparticles. Bioconjugate Chem., 31(5), 1408-16. [PubMed]

Miller, A. L., et al. (2019). Rapid conjugation of nanoparticles, proteins and siRNAs to microbubbles by strain-promoted click chemistry for ultrasound imaging and drug delivery?. Polym. Chem., 10, 705-717. [Publishing]

Huynh, V., et al. (2018). Competitive Affinity Release for Long-Term Delivery of Antibodies from Hydrogels. Bioconjugate Chem., 57(13), 3406-10. [PubMed]

Nedrow-Byerst, J.R., et al. (2013). PSMA-targeted SPECT agents: mode of binding effect on in vitro performance. Prostate., 73(4), 355-62. [PubMed]

Click Chemistry Tools（CCT）一直致力于不斷開發和擴展一系列連接產品。他們利用特別新的研究成果研發生產出新穎的交聯和標記試劑。產品被廣泛用于藥物研發、癌癥治療以及各類診斷技術等。目前CCT的產品線主要包括：Azides（Biotin-Azides）試劑、Bis-sulfone交聯試劑、DBCO試劑、TCO試劑、Terminal Alkyne試劑、Tetrazine試劑、標記試劑盒以及分選用底物等。艾美捷科技是Click Chemistry Tools（CCT）的中國代理商，為科研工作者提供優質的產品與服務。