Immundiagnostik：連蛋白Zonulin檢測試劑盒

Zonulin（連蛋白）是一種參與上皮和內皮屏障功能調節的蛋白質，對腸粘膜細胞緊密連接的調節對于維持屏障內環境的平衡至關重要，zonulin是目前唯一已知的細胞間緊密連接的生理調節劑，參與大分子的運輸和耐受/免疫反應平衡。當連蛋白與腸的上皮細胞結合時，會誘導信號級聯。這種級聯分解了腸壁的細胞旁緊密連接。腸壁的緊密連接是允許分子從腸腔轉移到血流的兩種方式之一，反之亦然。當腸道中的連蛋白水平增加并失去平衡時，這些連接點會打開得更寬，并保持更長時間。這些加寬的入口點允許較大的大分子進入血液或腸腔。通過這些缺口的分子可以增加身體的自然免疫反應，引起炎癥和一些自身免疫性疾病。

與 Zonulin 水平升高相關的疾?。?/p>

• 1型糖尿病

• 類風濕關節炎

• 乳糜瀉

• 肝病

作為專業的生命科學醫藥原料供應商，艾美捷科技為您推薦Immundiagnostik榮譽產品，連蛋白Zonulin檢測試劑盒：適用于血清（Serum）和糞便（stool）樣本！

* Immundiagnostik榮譽出品..僅供科研使用，不得用于醫療.

Zonulin產品已發表文章：

• Parker, Jim, Claire O’brien, and Jason Hawrelak. "A narrative review of the role of gastrointestinal dysbiosis in the pathogenesis of polycystic ovary syndrome." Obstetrics & Gynecology Science 65.1 (2022): 14-28.

• Kleppe, Malin M., et al. "Intestinal barrier integrity in anorexia nervosa (a pilot study)." International Journal of Eating Disorders (2022).

• Meira de-Faria, Felipe, et al. "Colonic paracellular permeability and circulating zonulin-related proteins." Scandinavian Journal of Gastroenterology 56.4 (2021): 424-431.

• Tatucu-Babet, Oana A., et al. "Serum zonulin measured by enzyme-linked immunosorbent assay may not be a reliable marker of small intestinal permeability in healthy adults." Nutrition Research 78 (2020): 82-92.

• Xu, Yiyi, et al. "Inflammatory bowel disease and biomarkers of gut inflammation and permeability in a community with high exposure to perfluoroalkyl substances through drinking water." Environmental Research 181 (2020): 108923.

• Scherf, Katharina Anne, et al. "Cofactors of wheat-dependent exercise-induced anaphylaxis do not increase highly individual gliadin absorption in healthy volunteers." Clinical and translational allergy 9.1 (2019): 1-12.

• Kanerva, Sonja. "Assessment of immunological methods for quantification of human zonulin and the effects of intestinal bacteria on zonulin secretion in vitro." (2019).

• Ajamian, Mary, et al. "Serum zonulin as a marker of intestinal mucosal barrier function: May not be what it seems." PloS one 14.1 (2019): e0210728.

• Shariatpanahi, Zahra Vahdat, et al. "Effects of early enteral glutamine supplementation on intestinal permeability in critically ill patients." Indian Journal of Critical Care Medicine: Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine 23.8 (2019): 356.

• Scheffler, Lucas, et al. "Widely used commercial ELISA does not detect precursor of haptoglobin2, but recognizes properdin as a potential second member of the zonulin family." Frontiers in endocrinology 9 (2018): 22.

• Mokkala, K., et al. "Evaluation of serum zonulin for use as an early predictor for gestational diabetes." Nutrition & diabetes 7.3 (2017): e253-e253.